Discussion about this post

User's avatar
Josh Mitteldorf's avatar

"You won" is a gesture of resignation and resentment.

Scott -- we were never trying to defeat you -- we were trying to save your life. We were trying to keep your heart intact.

Expand full comment
Tonya's avatar

Based on his assumption that those who didn't get vaccinated made their decision based on distrust of the "authorities," not necessarily on facts, and his statement,

"Your position is going from the weakest to the strongest," he still believes that we were lucky; we couldn't have known that we would end up in the better position.

Yet the VRBPAC documents were available before the shots were rolled out. I don't think my position was ever the weakest. It wasn't ever "analytics vs heuristics".

The following benefits and risks were unknown at the time the COVID-19 vaccines from both Moderna and Pfizer-BioNTech were first given Emergency Use Authorization by the FDA in December 2020.

They can be found on pages 48-51 of the Moderna VRBPAC document, and pages 46-49 of the Pfizer VRBPAC document.

(VRBPAC= Vaccines and Related Biological Products Advisory Committee)

Moderna document:

https://www.fda.gov/media/144434/download

Pfizer document:

https://www.fda.gov/media/144245/download

Unknown Benefits/Data Gaps:

*Duration of protection

*Effectiveness in certain populations at high-risk of severe COVID-19

*Effectiveness in individuals previously infected with SARS-CoV-2

*Effectiveness in pediatric populations

*Future vaccine effectiveness as influenced by characteristics of the pandemic, changes in the virus, and/or potential effects of co-infections

*Vaccine effectiveness against asymptomatic infection

*Vaccine effectiveness against long-term effects of COVID-19 disease

*Vaccine effectiveness against mortality

*Vaccine effectiveness against transmission of SARS-CoV-2

Unknown Risks/Data Gaps:

*Safety in certain subpopulations

*Adverse reactions that are very uncommon or that require longer follow-up to be detected

*Vaccine-enhanced disease

Expand full comment
258 more comments...

No posts