Nice article. Much history is yet to surface, but I appreciate the ongoing depth examination of this complex story, uninhibited by a static point of view. You have proven to be free of said static point of view. I feel that commenting people need to be more cautious of the tales they believe in. Many are undoubtedly true enough to be said, some not so much. Literal demonstration of proof is always acceptable, otherwise it's point of view noise.
Japan, where I live, is still pushing the PCR as if it were the gold standard.
It is frustrating how few Japanese remember, or were even informed, that former Tanzania President John Magufuli's health director found papaya, goats, and motor oil all had something in common. They tested positive for the virus according to the PCR test.
The big question — will enough socially pro-active people wake up to flip the dark tipping point aimed at us?
p.s. As of the last week of Aug., I had a chat with the surgeon who will be cutting a thyroid tumor from my throat next month. He mentioned that on the day of admission to the hospital, I will be given a PCR test, and if it comes up positive, everything is cancelled for at least 70 days. He could see I was smiling beneath my mask through the wrinkles at the corners of my eyes ... but to verify, I asked him how do the medical authorities know whether a PCR positive test is detecting a potentially infective virus, or the viral fragments after having caught and recovered from CoVid? 'Se desu ne!' he emphatically answered ... as if happy to find a patient who also realized the policy is nonsense. I have repeatedly been in close, sometimes physical contact with about 2,500 elementary and Jr. High school students for about a year and half now. If I haven't caught and recovered from the 'vid' by now, chances are I am not going to catch it. Still, the doctor said to reassure others, we must comply. Pretty much sums up the purpose of Japan's much vaunted preference of 'harmony' over 'human rights' ... not to mention its value over following the science.
Yes, I watched a bunch of Dr. Ramani's videos a few years ago when I was trying to understand some narcissists and borderline people I'd butted heads with over the years. She speaks with great clarity on the topics. I haven't watched her since, so I'd forgotten her name. I may find the right time to reach out to her when I'm focused on some aspect of the Kunlangeta and want a conversation partner to talk it through with who has all the detailed knowledge and deep experience that I don't (but do my best to intuit and research).
read a book a few years back called Ponerology: a science of evil for political purposes written by a professor in Canada. His theory included that our psychopaths are drawn to professions where they can do the most harm, and they will have the most control over others. Like Davos, or the NIAID .
Thanks for the heads up AJ. New book for me ... and intrigued, I found that it is free reading on my Kindle unlimited plan. I am moving this one higher in my to-read list, as I think it is hitting the psychological nail on the head behind the power shift.
Wooowee! GREAT word for the day ... psychopaths even in peaceful communities. Yes. I am convinced that a combination of the dysfunctions of scale (maybe Gödel's Incompleteness Theorem is one great mathematical metaphor for it) and the salience of dark-triad personality traits and behavior is what has periodically lead to the great evil events of history ... and possibly the built-in, self-destruct button of our species.
I've been on Quora for 7 years, but it is only in the last few months I've started shifting to here and a few ''private'' groups. Igor Chudov, Batcattitude, Jestre, Steve Kirsch, Katherine Watt, Sage Hana, Tess Lawrie, Margarette Anna Alice, 2nd Smartest Guy, The Naked Emperor, etc. ... and that is just substack alone. Drowning in information, though getting a bit better at spotting and dismissing the b.s.
From what I've seen so far, your info is good stuff. It will take a while to work up my own ... but I've been in Japan at the fringes of academia for 40 years now, so will be be hoping for new readers myself.
One potentially useful and unique angle ... my 40 years of marginalization as a foreigner, overlapping with being an educational idealist and easy target for dark-triad personality types, and the general pattern of the collective identity of groups as having a high correlation with dark-triad personality types (MLK's Letter from a Birmingham Jail addresses that) ... all triangulate well with what is now happening world wide. Just a few years ago, my story, in the eyes of apologists for Japanese exceptionalism, would have been dismissed as the complaints of a loser. Now, my experience is a post-hoc fractal of what is happening to the average wage-slave.
Whaaat?! They vaccinated tigers and other animals? (are you kidding me?)
Whenever you think it can not get worse, they will surprise you with another action.
And soon we will see videos of Billy, Klausy, Tony and all their other friends running through the deserts with needles in their hands, trying to catch all lions and other animals in order to administer a lifesaving covid vaccine? Of course this is necessary, otherwise they can never reach "herd" immunity. And since there are so many lions and tigers hospitalized due to covid, it is absolutely necessary to vaccinate them. I always see lions lying on the street here due to covid (hundreds of lions per day) and being picked up by paramedics.
And please consider that one of these lions could -while chasing it- get too close to a zebra and infect it with the Sars-COV-2 Omicron variant. Poor zebra. How are we going to tell lions that they have to keep a distance of at least two meters while chasing and eating another animal? So all this shows you that we have to vaccinate them in order to reduce their risk by 95%. Maybe nearly 100%. The 95% are probably an underestimate.
"Under laboratory conditions, house flies acquired and harbored infectious SARS-CoV-2 for up to 24 h post-exposure. In addition, house flies were able to mechanically transmit SARS-CoV-2 genomic RNA to the surrounding environment up to 24 h post-exposure."
Fish literally have NO LUNGS and thus it is impossible for them to suffer from a respiratory disease like the flu/Covid-19/et al.
Also, if you want to learn more about vaccines in animals, look at South Korea. For a while there, they made it mandatory to have house pets tested AND vaccinated, plus they took the extra ridiculous step of putting cats who "tested positive" in "quarantine centers". Beyond ridiculous.
We'll have to vax every rat, cat, bat, gnat, and sea cucumber at exactly the same time so that covid doesn't mutate again.... but it will be worth it since Pfizer Moderna will make so many billions!!!
Anecdotal, I know, but all 4 humans in my household got Omicron about 2 months ago but neither of our pets got sick during that time and were definitely exposed (house rabbit and puppy) . My puppy wanted to lie next to me in bed when I was sick so was in very close contact.
Compared with humans, most animals (including dogs) produce their own vitamin C. When they are sick or stressed (and probably also when they are exposed to pathogens), they produce a much higher amount (10 times higher than normal). For example, when sick, a goat that weighs 70 kg may produce up to 100 Grams of Vitamin C per day. Compare this with the <100 mg of vitamin C that most people eat per day.
This might be one of the reasons why many animals are more resistant. I could imagine other reasons as well. Probably another bacterial composition in their oropharynx, in their gut etc... They need a much stronger "microbiota" which defends them because, for example, carnivores eat raw meat which contains pathogens... So they probably have a better defense against several pathogens than humans.
I had a horrid case of delta, while on vacation with my 3yr old granddaughter. We shared a bed and a bedroom, she never even sneezed. 2 cats in the house were never taken by ambulance to the emergency vet. I wish I had been that lucky.
Re: The Hydrogel patent US8415325B2 is listed in the Moderna patent, here. Official Biochemical and Statistical Evidence 100% confirms Moderna created Covid-19 patented in 2013
Covid-19 means: 19 nucleotide sequence and not 2019 at all.
By The Exposé on March 3, 2022
Evidence has emerged which proves beyond a reasonable doubt that the pharmaceutical giant Moderna, the company that has made billions through the sale of an experimental Covid-19 injection, actually created the Covid-19 virus.
They cited a Paper by Scientists in India, Switzerland, Italy and the US (cautiously entitled: MSH3 Homology and Potential Recombination Link to SARS-CoV-2 Furin Cleavage Site) in which they calculated that the chances of a 19 nucleotide sequence patented by Moderna randomly appearing in Covid-19 in circumstances where it does not appear anywhere else in nature are 1 in 3 trillion.
Furthermore they did not merely apply for a patent on 2016 February 4 with US9587003B2: as reported in the Daily Mail. They actually applied on 2013 December 16 for 4 patents with US9149506B2, US9216205B2, US9255129B2, US9301993B2:as well.
So Moderna had developed the 19 nucleotide gene sequence containing the Furin Cleavage Site which gives Covid19 its infectivity to humans by patented gain of function research as early as 2013, 6 years before the Wuhan outbreak took place. Not 3 as reported in the Mail and virally elsewhere..
Covid-19 was not made in 2019. It was made from the 19 nucleotide Moderna specific chimeric (CGG for AGA) furin cleavage site (in 2013) which does not occur anywhere in nature. And every Covid death and every Covid vaccine death is parked squarely on the doorstep of ModeRNA and The Covid19 makers, the genetic vaccine makers. their funders and their promoters, which include almost every government and public sector and health service in the world, are therefore guilty of Genocide and crimes against humanity. They have pushed genetic rape and sickness and death onto half of the population of the world in order to enrich the pockets of Pharmaceutical Companies. Governments and Public sectors around the world have abandoned their health service regulation to billionaires and heartless corporations (me: and to make we humans, Trans Humans and now, the vaccinated, without any human rights whatsoever
The Expose
2) Dr Ugur Sahin, the COVID-19 vaccine he designed for Pfizer was designed in just few hours in a single day (on a computer) on January 25, 2020. No other vaccine in history has been created and manufactured so quickly. Previously, the fastest vaccine ever developed took more than four years. co-founder of BioNTech Not only that, Pfizer Chairman (((Albert Bourla))) hasn’t gotten around to having his shot, or Dr Ugur Sahin, last I knew. And it went from laboratory straight into human arms without any animal testing first - mRNA never used in humans ever before - doesn't that strike you as odd?
Obviously, no virus was present, when this vaccine was made on a computer and a Covid infection, was not the basis of the vaccine creation, in the first place.
Documents by Pfizer Show BioNTech Paid FDA $2,875,842.00 "Drug User Fee" for COVID-19 Vaccine Approval
Vaccine Impact
3) The Hydrogel patent US8415325B2 is listed in the Moderna patent, here. Hydrogels are also mentioned in a second Moderna patent, here. Hydrogel is listed in the Johnson & Johnson patent, here. Hydrogels are made from Graphene Oxide. Nobody can deny the evidence that Graphene Oxide is in the shots.
"The “smoking gun” if you will is CTCCTCGGCGGGCACGTAG. That is the 19 nucleotide genome sequence of SARS-CoV-2. The chances of this sequence happening in nature are less than one in a billion. There was no such virus containing this sequence prior to 2020. Every patent in BLAST that contains this near-impossible sequence is owned by Moderna, and all of them predate SARS-CoV-2.
Dr. Michael Worobey is the Head of Ecology and Evolutionary Biology at the University of Arizona. He attempted to prove that SARS-CoV-2 is a product of nature. “Dr. Syed” responded and completely dismantled Dr. Worobey arguments in one tweet. The latter disappeared and did not respond further."
The most deadly outbreaks affected very specific ethic groups. Why, for the vast majority, did it present as a common cold?
Oh my gosh, I just remembered when Denmark slaughtered thousands of mink because they supposedly had Covid-19, and then they "came back to life" when their graves started bouncing up and down. Friggin' nightmare fuel.
It must have been climate change that killed those tigers? Or maybe they were doing too much gardening, or baking apple pies?
"The reason no animals tested positive for Covid in 2020," said Ja Beded, but then Ja keeled over dead. Another case of so, so SADS. Local doctors speculated his death was due his not having received his seventh booster until 3mths and 2 full days after the 6th.
Re social engineering using "conservation NGOs" -- like Daszak's Eco Health Alliance?
From Wikipedia:
Founded under the name Wildlife Preservation Trust International in 1971 by British naturalist, author, and television personality Gerald Durrell, it became The Wildlife Trust in 1999. In the fall of 2010, the organization changed its name to EcoHealth Alliance. The rebrand reflected a change in the organization's focus, moving from solely a conservation nonprofit which focused mainly on the captive breeding of endangered species, to an environmental health organization with its foundation in conservation.
Vaccinating animals? Tigers? How much worse can this get? Here I thought we were finally getting the truth out about vax injuries and possibly rounding a corner. CDC admitting what many have known for 2 years. But now we learn about animals and going back way before we thought it started. Utter nightmare.
Thanks. This was a good interview, and the thermographic images showing the large blood clots is another proof along with the embalmers. So sad though.
My experience is with NAC other antioxidants - Precursors of glutathione reverse blood clots and prevent and reverse the aggregation of amyloid plaque formations
There is science behind, if you're interested. Thank you for your comment
Toxicity and immunogenicity concerns related to PEGylated-micelle carrier systems: a review - PMC (nih.gov) Sci Technol Adv Mater. 2019; 20(1): 324–336.
Published online 2019 Apr 15. doi: 10.1080/14686996.2019.1590126
In vivo Studies on Pharmacokinetics, Toxicity and Immunogenicity of Po | IJN (dovepress.com)
However, it should be emphasized that long-lasting elevated levels of cytokines can lead to inflammation-mediated toxicity.46,47 For example, high levels of GM-CSF, IFN-γ, IL-23, IL-6, and IL-17α were suggested to be involved in the development of organ-related autoimmune inflammatory diseases.48
Etc.
It is an unbelievable crime over something what for most people is completely not lethal, especially with the right treatment
PEGylation and anti-PEG antibodies - ScienceDirect
Abstract
Polyethylene glycol (PEG) is generally considered a stealth polymer that is universally used to extend the circulation times and enhance the therapeutic efficacy of nanocarrier-based and/or protein therapeutics. Nonetheless, in contrast to the general concept that PEG is nonimmunogenic, a growing body of literature has emerged declaring PEG to be immunogenic, which is manifested by the robust production of anti-PEG antibodies. The existence of such anti-PEG antibodies has been intimately correlated with an impairment of therapeutic efficacy in tandem with the development of severe adverse effects in several clinical settings employing PEGylated-based therapeutics. This chapter is a discussion of the mechanisms beyond anti-PEG immunity as well as the implications that preexisting and treatment-induced anti-PEG antibodies is exerting on the fate of PEGylated products. In addition, several alternative technologies beyond PEGylation are highlighted.
Full article: PEGylated liposomes: immunological responses (tandfonline.com)
ABSTRACT
A commonly held view is that nanocarriers conjugated to polyethylene glycol (PEG) are non-immunogenic. However, many studies have reported that unexpected immune responses have occurred against PEG-conjugated nanocarriers. One unanticipated response is the rapid clearance of PEGylated nanocarriers upon repeat administration, called the accelerated blood clearance (ABC) phenomenon. ABC involves the production of antibodies toward nanocarrier components, including PEG, which reduces the safety and effectiveness of encapsulated therapeutic agents. Another immune response is the hypersensitivity or infusion reaction referred to as complement (C) activation-related pseudoallergy (CARPA). Such immunogenicity and adverse reactivities of PEGylated nanocarriers may be of potential concern for the clinical use of PEGylated therapeutics. Accordingly, screening of the immunogenicity and CARPA reactogenicity of nanocarrier-based therapeutics should be a prerequisite before they can proceed into clinical studies. This review presents PEGylated liposomes, immunogenicity of PEG, the ABC phenomenon, C activation and lipid-induced CARPA from a toxicological point of view, and also addresses the factors that influence these adverse interactions with the immune system. (...)
The presence of pre-existing anti-PEG antibodies might trigger further immunogenic responses to PEG when the human subjects receive PEGylated therapeutics [25,26]. These pre-existing and induced anti-PEG antibodies together may compromise the response to PEGylated medicines in the clinical settings [29–31]. (...)
4.1 Mechanism of the ABC phenomenon
According to Dams et al. [39], in animal models, a second dose of PEGylated liposomes, injected within a time interval of 5 and 21 days, was cleared very rapidly from the blood circulation. The ABC phenomenon showed two distinct phases: the induction phase and the effectuation phase. The induction phase followed the initial dose of PEGylated liposomes in which the biological system is ‘primed’. The effectuation phase occurs at day 3–7 after the initial dose in which a subsequent dose of PEGylated liposomes is rapidly cleared from systemic circulation [42]. (...)
5.2.4 Route and speed of intravenous administration
The intensity of the pulmonary hypertension is influenced by the route and rate of administration. It has been reported that administration of SUV in pigs by slow infusion suppressed the pulmonary hypertensive effect, compared to the effect observed with bolus intravenous injections [94]. These results can be accounted for by the elevation of blood anaphylatoxins levels, which are considered the rate limiting mediator in pulmonary vasoactivity [103]. Studies showed that the steady-state level of functional anaphylatoxins is controlled by the production rate and clearance rate of C3a and C5a in the plasma. Since the clearance rate is unaffected by the method of administration, anaphylatoxins levels in the blood would be proportional to the degree of complement activation induced by the injected liposomes, as well as the speed of liposome injection.
6. Toxicity relating to ABC phenomenon and CARPA
A few researchers have reported that repeated injection of empty PEGylated liposomes altered their pharmacokinetic behavior (the ABC phenomenon), which might lead to lower therapeutic efficacy and even unexpected side effects, if cytotoxic drugs were encapsulated [58,72,73]. In other than liposomes, it has been reported that repeated injections of long circulating organic-inorganic hybrid nanoparticles induced the ABC phenomenon, which substantially attenuated the passive targeting of 64Cu-labeled PEGylated nanoparticles in a murine model of peripheral arterial disease [105]. In addition, the PEGylated liposomal formulations including Doxil®, Ambisome®, Abelect®, and Amphocyl® showed acute immune toxicity represented in non-IgE mediated hypersensitivity reactions (CARPA) in a small percentage of individuals treated for the first time in the absence of pre-medication [21,75,94].
These findings and explanations taken together support the proposal that the binding of anti-PEG IgM to Doxebo/Doxil in blood explains complement activation, which entails anaphylatoxin production and opsonization of liposomes.
Mechanism of HSR to PEGylated Nanomedicines: Piecing the Steps Together
On the basis of a long list of evidence for a causal role of complement activation in certain liposome-induced HSRs (Supplement Table 1) we proposed earlier that CARPA represents a major mechanism of infusion reactions to a variety of nanoparticulate drugs and agents. (21,22) However, recently, the role of complement in infusion reactions has been questioned (23) on the basis of an experiment that showed no complement activation by a polystyrene nanoparticle in pig blood in vitro, although it caused pulmonary reactions in pigs in vivo. (24) Although the validity of these in vitro data and the generalization of conclusions was debated, (25,26) the ultimate question, what is the contribution of complement activation to nanoparticle-induced cardiopulmonary distress of pigs vis-à-vis other mechanisms, remained open. (...)
Our present data showing significant correlation between pulmonary hypertension and rise of sC5b-9 in the blood of animals sensitized for Ab-mediated C activation represent direct evidence that complement activation can play a causal role in the pigs’ cardiopulmonary distress. In addition, the acceleration of cardiovascular distress to pseudo-anaphylaxis in immunized animals displaying high anti-PEG IgM titer in blood, taken together with the increased C3 conversion by Doxil in immune vs naı̈ve pig serum and the accelerated clearance of anti-PEG IgM on the same time course as complement activation and the cardiopulmonary reaction proceeds, suggests a causal relationship not only between C activation and pulmonary reaction but also between anti-PEG IgM levels in blood and complement activation. These processes pieced together suggest the comprehensive reaction scheme in Figure 7, illustrating the sequence of reaction steps along an immuno-circulatory axis: first the binding of Abs to liposomes causing complement activation, liberation of anaphylatoxins and other complement cleavage products, and their stimulatory effects on allergy-mediating innate immune cells entailing the secretion of vasoactive and inflammatory mediators, which are responsible for the symptoms of HSRs. (...)
The Concept of “Primary ABC”
In ABC, studied for nearly two decades mainly in murine models, (30−35) the rapid clearance of liposomes has been attributed to the binding of anti-PEG IgM to the vesicles, entailing complement activation, opsonization, and rapid clearance by the MPS. These anti-PEG Abs were shown to be formed in splenic marginal zone B cells via T-cell independent immunization by a prior injection of PEGylated liposomes. (32−35) It is therefore a fundamental difference between the above “classical” ABC and our observations on rapid anti-PEG IgM clearance that the latter process occurs already after the first injection of liposomes; there is no priming (Figure 2B and C). Assuming that the anti-PEG IgM undergoing rapid clearance was liposome-bound, the finding suggests that preexisting, naturally occurring anti-PEG IgM can similarly remove liposomes as the induced Abs in “classical” ABC. Thus, the rapid decay of anti-PEG IgM shown in Figure 2B and C may reflect “primary” ABC with many of the attributes of “secondary” ABC. Accordingly, primary ABC and CARPA may represent “two sides of the same coin”, (35) raising the question of why HSR was never reported during secondary ABC in rats and mice. The most likely explanation is that these species have orders of magnitude lower sensitivity for HSRs than pigs or hypersensitive human. (29,36) It is the high sensitivity of the pig model for HSRs that enabled uncovering of this duality.
Criticism of the Porcine Model
The pig model used in this study has recently been claimed to be irrelevant to the average human patient and is therefore misleading for assessing the risk of nanomedicine-induced HSRs. (23,39−41) The reasons for this view included the difference of HSR rate in pigs and the average human, different underlying immune mechanisms, and the “globality” of cardiopulmonary reactions. To clarify possible misunderstandings that led to the above conclusions, it seems important to re-emphasize (18,19,25) that the pig model is not a traditional immune toxicology model where the toxicities of drugs on the immune system are assessed in healthy animals to predict possible adverse immune effects in immunologically normal humans. Like other animal models of allergy, the pig model is an allergic disease model, i.e., that of severe hypersensitivity of a small percentage of people to certain i.v. administered nanopharmaceuticals. Regardless of the underlying mechanism, the concordance with human symptoms (see below) enables the model to serve for identifying the hazard of hypersensitivity reaction to the tested drug in the case of hypersensitive patients. Also, certain cardiopulmonary and other physiological changes are quantitative and highly reproducible within the dynamic window of the test, where the adverse response is dose dependent. This allows using the model for the assessment of the risk that the tested drugs might cause HSR, to study the mechanism of these reactions and develop methods for their prevention.
Clinical Relevance of the Porcine CARPA Model
In keeping with the above claims on human relevance, our observations in the pig model show significant concordance with some recent clinical trial data. Namely, the “RADAR” and “REGULATE-PCI” trials with pegnivacogin (Revolixys kit) (42,43) were stopped because of life-threatening HSRs. The tested PEGylated aptamer caused anaphylaxis in 3/640 (0.46%) and 10/1605 (0.62%) patients, and reactions were observed exclusively in those who had high levels of preformed anti-PEG antibodies. (42,43) Importantly, the indications of complement activation (rises of C3a, Bb, drop of CH50) included C4d, a biomarker of classical pathway complement activation. (42,43) In agreement with the conclusion in the present study, the authors of the above-mentioned clinical study suggested anti-PEG Ab-triggered complement activation (i.e., CARPA) as the underlying cause of anaphylactic reactions, although they assign the reactions to anti-PEG IgG, rather than anti-PEG IgM (which was not measured). In another clinical study on the frequent and severe HSRs to pegloticase (Krystexxa), a PEGylated recombinant porcine enzyme (uricase) used for the treatment of refractory gout, the HSRs were shown to be correlated with the preexisting and induced anti-PEG Abs and rapid loss of the drug’s efficacy. (14,44) Yet another testimony to the clinical relevance of the pig model is the recent FDA approval of a transthyretin-directed small inhibitory RNA-containing nanoparticle (patisiran, Onpattro), whose safe administration protocol was developed, in part, using the porcine CARPA model. (45)
Perspective
This study provided experimental support for the concept that PEGylated liposome-induced CARPA, whose worst manifestation is pseudo-anaphylactic shock, proceeds along the complement–circulatory system axis, via acute cascadic activation of innate humoral and cellular immunity. This information may help to better understand and, hence, more efficiently predict and prevent HSRs to PEGylated and other nanopharmaceuticals. Furthermore, the listed evidence of concordance between the physiological and immune responses to PEGylated nanoparticles in pigs and humans, as well as the example of using the model by the biopharma industry, provides strong support for the human relevance and use of the porcine CARPA model for hazard identification in preclinical safety studies.
Polyethylene glycol (PEG)-coated nanopharmaceuticals can cause mild to severe hypersensitivity reactions (HSRs), which can occasionally be life threatening or even lethal. The phenomenon represents an unsolved immune barrier to the use of these drugs, yet its mechanism is poorly understood. This study showed that a single i.v. injection in pigs of a low dose of PEGylated liposomes (Doxebo) induced a massive rise of anti-PEG IgM in blood, peaking at days 7–9 and declining over 6 weeks. Bolus injections of PEG-liposomes during seroconversion resulted in anaphylactoid shock (pseudo-anaphylaxis) within 2–3 min, although similar treatments of naı̈ve animals led to only mild hemodynamic disturbance. Parallel measurement of pulmonary arterial pressure (PAP) and sC5b-9 in blood, taken as measures of HSR and complement activation, respectively, showed a concordant rise of the two variables within 3 min and a decline within 15 min, suggesting a causal relationship between complement activation and pulmonary hypertension. We also observed a rapid decline of anti-PEG IgM in the blood within minutes, increased binding of PEGylated liposomes to IgM+ B cells in the spleen of immunized animals compared to control, and increased C3 conversion by PEGylated liposomes in the serum of immunized pigs. These observations taken together suggest rapid binding of anti-PEG IgM to PEGylated liposomes, leading to complement activation via the classical pathway, entailing anaphylactoid shock and accelerated blood clearance of liposome–IgM complexes. These data suggest that complement activation plays a causal role in severe HSRs to PEGylated nanomedicines and that pigs can be used as a hazard identification model to assess the risk of HSRs in preclinical safety studies.
An unresolved issue with such PEGylated nanopharmaceuticals is their recognition by the immune system manifested in non-IgE-mediated (pseudoallergic) hypersensitivity reactions (HSRs), an adverse event commonly called infusion reaction. (1−7) PEGylated nanomedicines that have been reported to cause such reactions include PEGylated liposomal doxorubicin (Doxil/Caelyx), (8) PEGylated G-CSF (pegfilgrastim, Neulasta), (9) PEGylated erythropoetin (mono-mPEG-epoetin-β, Mircera), (10) PEGylated recombinant human factor VIII (Adynovate), (11) and PEGylated phenylalanine ammonia lyase (pegvaliase-pqpz, Palynziq), (12) with at least three formulations withdrawn from clinical use partly because of severe HSRs: PEGylated EPO-mimetic peptide (peginesatide, Omontys), (13) PEGylated urate oxidase (pegloticase, Krystexxa), (14) and a PEGylated IXa blocker RNA aptamer (pegnivacogin, Revolixys). (15)
The symptoms include shortness of breath, facial redness and swelling, chest pain, back pain, flashing, rash, chills, panic, and fever that mostly arise shortly after the first treatment, although reactions starting later or after repeated treatments are also observed. In most cases the problem spontaneously resolves or can easily be controlled; however, occasionally, the reaction can escalate into pseudo-anaphylaxis, a severe, occasionally lethal form of infusion reactions resembling anaphylaxis without IgE playing a role. It is also known as anaphylactoid reaction, or anaphylactoid shock.
In order to better understand these reactions and help their prediction and prevention, the present study used the porcine complement activation-related pseudoallergy (CARPA) model, (16−19) which was shown previously to display typical symptoms of cardiac anaphylaxis, (16) whereupon the cause of sudden death is shock with cardiac arrest. We used the model for uncovering the immune mechanism underlying the HSRs to PEGylated drugs, taking PEGylated liposomal doxorubicin (Doxil/Caelyx) and its drug-free formulation, placebo Doxil (Doxebo) (20) as model agents. By providing evidence for a causal relationship among the induction of anti-PEG antibodies, complement activation, and pseudo-anaphylaxis, the present data highlight the mechanism of Doxil-induced severe HSRs and use of the pig model in understanding and predicting this type of immune toxicity of PEGylated nanopharmaceuticals. (...)
A single i.v. treatment of pigs with low (0.1 mg phospholipid (PL)/kg) Doxebo led to a massive rise of anti-PEG IgM and a parallel smaller rise of anti-PEG IgG antibodies (Abs) (Figure 1). Panels A and B show the titers on linear and logarithmic scales, respectively, the latter amplifying the lower region of titer changes. The rise of Abs started on day 3 following treatment, and the titers reached a peak between days 7–9 and returned to close to baseline after 4–6 weeks. Essentially similar, although less expressed titers were obtained when whole Doxebo was used as antigen in the ELISA (...)
Amplified Reactogenicity of PEGylated Liposomes in Pigs Immunized with Doxebo
If anti-PEG IgM plays a causal role in Doxil-induced HSRs, as suggested by the data in Figure 2, intentional elevation of these Abs by way of immunization with Doxebo (Figure 1) is expected to increase the reactogenicity of PEGylated liposomes. The experiments shown in Figure 3 proved this prediction with unexpected power. Bolus injections of Doxebo and Doxil in 5 immunized pigs led within 2 min to life-threatening HSR in one and lethal pseudo-anaphylaxis requiring resuscitation in 4 animals, regardless of the timing of the test within the 2–6-week window of seroconversion.
As illustrated with the surviving animal in Figure 3A, the PAP considerably increased in both amplitude and duration compared to that seen in naı̈ve animals (Figure 2A), and we observed significant SAP and heart rate (HR) changes even after repeated injections of liposomes (Figure 3A). This implies loss of tachyphylaxis (self-tolerance), which is a characteristic feature of Doxil reactions in naı̈ve pigs and is thought to be due to depletion of natural antibodies, (20) for which we obtained evidence in Figure 2B and C. Thus, the consumption of reactive antibodies during the first reaction was not enough to deplete them to nonreactive levels. Figure 3B illustrates the deadly pseudoanaphylaxis with maximal rise of PAP and shock developing within 2 min. The panel also illustrates the moments of resuscitation with cardiac massage and epinephrine, resulting in an overshot of SAP. Figure 3C shows that these severe reactions were associated with extensive flushing and rash within 3 min.
Figure 3. Reactogenicity of PEGylated liposomes in pigs immunized with Doxebo. (A) Hemodynamic changes in one out of 5 animals, showing severe but not lethal responses to repetitive injections of the specified liposome doses 4 weeks after immunization. (B) pseudo-anaphylactic shock in another pig illustrating the reaction of 4 out of 5 immunized pigs tested in the 2–6-week interval after immunization. In real-time hemodynamic tracings, the large-amplitude noise coincided with cardiac massage. (C) Abdominal region of the skin before (“control”) and 3 min after the injection of Doxebo, showing confluent skin flushing and rash observed in all 5 pigs. The objects in the pictures include a three-way stopcock connected to a pressure transducer and the syringe used to inflate the spinnaker balloon of the Swan-Ganz catheter (see Materials and Methods).
Regarding the dose–effect relationship between anti-PEG IgM and HSRs in immunized pigs, apart from the need or no need for resuscitation, the reactions were quantitatively indistinguishable regardless of the actual—significantly elevated—titers of anti-PEG IgM at the time of the experiment. This suggests that the significant correlation between anti-PEG IgM and HSR obtained for naı̈ve animals (Figure 2D) is not applicable in immunized pigs, as the amount of anti-PEG IgM in blood far exceeds the plateau of the dynamic range of dose–effect relationship, whose exact limits remain to be determined.
The data in Figure 3 reveal effective sensitization of animals for PEGylated liposome-induced HSRs by immunization-induced rise of anti-PEG IgM, which is consistent with a causal role of these Abs in the phenomenon. As for the exact mechanism of the cause–effect relationship, considering that antigen-bound IgM is one of the most powerful activators of the complement system via the classical pathway, and that there is a large body of evidence for the CARPA theory, i.e., that complement activation plays a causal role in many HSRs (Supporting Table 1), complement activation represents an obvious link between anti-PEG IgM and HSR. However, such a link has had only indirect experimental support to date, and the elevation of complement activation byproducts in pig blood during HSRs has never been shown. (16−21) (...)
Anaphylaxis to the first COVID-19 vaccine: is polyethylene glycol (PEG) the culprit? - British Journal of Anaesthesia (bjanaesthesia.org)
The COVID-19 vaccine from Pfizer–BioNTech recently introduced in the UK, USA, and other countries is a messenger RNA (mRNA)-based vaccine (tozinameran, BNT-162b2) using lipid nanoparticles to facilitate the transport of mRNA into cells.
The vaccine contains a number of excipients and lipids, one of them based on PEG-2000. This is currently the only excipient in the vaccine with recognised allergenic potential. The severity and rapid onset of the two reported reactions to the vaccine further increase suspicion towards PEG.
Allergy to excipients is often overlooked because of a lack of knowledge about their allergenic potential. However, allergy to PEG, also often called macrogol, has been reported with increasing frequency over recent years,
Patients have usually had repeated systemic allergic reactions/anaphylaxis before diagnosis. (...)
The mechanism of sensitisation to PEGs is unknown, but from the cases described in the literature and our personal experience with a total of 18 patients with PEG allergy, there is no reason to believe that existing inhalational or food allergies predispose to PEG allergy. However, PEG allergy may be suspected in patients with very severe reactions to drugs where the cause is unconfirmed, or patients with repeated immediate-type reactions to several structurally unrelated drugs or other products containing PEG.
Exclusion criteria for the clinical trials of the vaccine included individuals with known hypersensitivity to vaccines, or with a history of allergy, hypersensitivity, or intolerance to the COVID-19 vaccine or its excipients according to the registration of the trials on ClinicalTrials.gov. At the FDA advisory committee meeting, the cases of anaphylaxis in the UK were discussed at length. The advisory committee voted 17 to 4 in favour of granting Pfizer emergency approval for the vaccine, which was granted on December 11, 2020. The FDA requested that a warning be added to the product information that medication to treat immediate-type hypersensitivity reactions should be available where vaccinations take place. Also, the FDA advised that the vaccine should be contraindicated in patients with a severe allergic reaction to the first dose of vaccine, or with known hypersensitivity to any ingredient/component of the vaccine. Finally, a stringent surveillance system is to be initiated to monitor adverse effects of the vaccine with monthly reporting.
The individuals who have had allergic reactions to the vaccine in the UK should be urgently investigated to determine the mechanisms behind the reactions and the potential involvement of PEG. The reported history of previous severe allergies should be scrutinised and their causes determined.
Investigations for allergy to PEG currently include skin testing,but in vitro tests may be in the pipeline.
As systemic allergic reactions have been reported in connection with skin prick testing in PEG-allergic patients, the development of a reliable in vitro test is urgently needed.
PEG has not been used previously as an excipient in vaccines with this potential for wide dissemination, but even if PEG is concluded to be the cause, allergy to this excipient is also very rare. As soon as a plausible explanation for the suspected vaccine reactions has been found, clear recommendations can be made for a safe vaccination strategy.
Pseudo-anaphylaxis to Polyethylene Glycol (PEG)-Coated Liposomes: Roles of Anti-PEG IgM and Complement Activation in a Porcine Model of Human Infusion Reactions | ACS Nano
PEG on its own is another huge topic regarding its toxicity and ability to sensitize people (Polyethylene Glycol) as a novel technology and the issue of sensitizing recipients and allergy/severe adverse reaction
In connection with PGE - where are the studies??? Because, as demonstrated below, we are taking entire humanity on a totally unknown path.
Are we going to let this experiment to continue on the entire human race?
We are on the level of 3rd and 4th booster (even 5th) - but even Fauci says they do not know if 3rd booster is enough, or 4th, or what else, after, while Minister "of Health" of Canada claims we needto have a "booster" every 9 months!. Because simply it was not possible to do more testing because of the time issue. So we are conducting phase 3 on the humanity, and we are offering endless boosting with literally NO existing data and even further testing!
So I want to also add to this the fact, that using just Polyethylene Glycol is HIGHLY questionable. We already have allergy to it. Sensitizing people, create even more danger. So what about additional doses and PEG?
So how is this possible those regulators, vaccine companies, governments are dragging the entire humanity, including children and pregnant into such an unchartered territory?
Where is the real risk/benefit scenario, if we do not know what comes after the 5th, 6th etc. boosters, or even 4th one, if simply the experiment is not reaching so far? Let's just look into future: Does Pfizer, or FDA or anyone know? How many boosters we are going to be given? Australia bought 10-14? Why? Where is the science? Are we all lab rats?
Questions regarding JUST PEG:
1. How many more boosters is needed?
2. How many our immune system can handle?
3. What about sensitizing people with more PEG?
4. WHERE IS EVALUATION of ADVERSE REACTIONS in regards to possible adverse reactions from PGE (autoimmune problems, allergies, etc.)?
So, when FDA took the decision on injecting the people, they also said this will be monitored. Is it? Is there an active group of scientists evaluating it?
There is no evaluation, nothing, no real science behind, no plan and safety data for anyone in longer term. Why do we need to agree on such an experiment, or be coerced or forced?
Now they can just inject new "boosters" without ANY studies.
Even, just for PEG sensitivity question level:
View of Worse Than the Disease? Reviewing Some Possible Unintended Consequences of the mRNA Vaccines Against COVID-19 (ijvtpr.com)
Adjuvants, Polyethylene Glycol, and AnaphylaxisAdjuvants are vaccine additives intended to “elicit distinctive immunological profiles with regard to the direction, duration, and strength of immune responses” from the vaccines to which they are added (Liang et al., 2020). Alum or other aluminum compounds are most commonly utilized in traditional vaccines, and they elicit a wide range of systemic immune activation pathways as well as stromal cell activation at the site of the injection (Lambrecht et al., 2009; Danielsson & Eriksson, 2021).An aluminum-based adjuvant was determined not to be optimal for a coronavirus vaccine, so other solutions were sought (Liang et. al., 2020). A solution presented itself in the form of the widely used pharmaceutical ingredient polyethylene glycol, or PEG. A limiting factor in the use of nucleic-acid-based vaccines is the tendency for the nucleic acids to be quickly degraded by nuclease enzymes (Ho et al., 2021). Regarding the RNAse enzymes targeting injected mRNA, these enzymes are widely distributed both intracellularly (primarily within the lysosomes) (Fujiwara et al., 2017) and extracellularly (Lu et al., 2018). To overcome this limitation, both mRNA vaccines currently deployed against COVID-19 utilize lipid-based nanoparticles as delivery vehicles. The mRNA cargo is placed inside a shell composed of synthetic lipids and cholesterol, along with PEG to stabilize the mRNA molecule against degradation. The vaccine produced by Pfizer/BioNTech creates nanoparticles from 2-[(polyethylene glycol)-2000]-N,N-ditetradecylacetamide, or ALC-0159, commonly abbreviated simply as PEG (World Health Organization, 2021, January 14). The Moderna vaccine contains another PEG variant, SM-102, 1,2-dimyristoyl-rac-glycero-3-methoxypolyethylene glycol2000 (World Health Organization, International Journal of Vaccine Theory, Practice, and Research2(1), May 10, 2021 Page | 482021, January 19). For convenience we will abbreviate both PEG-modified lipids as PEG, and refer to the vaccines as PEGylated according to standard nomenclature. The lipid shell plays a triple role. First, it protects the genetic material from degradation prior to cellular uptake. Second, the lipid shell, which also contains cholesterol, facilitates cellular uptake through fusion with the lipid membrane of the cell and subsequent endocytosis of the lipid particle, invoking naturally existing processes. And finally, it acts as an adjuvant (Ho et al., 2021). It is in this latter role asimmune stimulant that most concerns have been raised regarding the widespread use of PEG in an injection therapy. In an article published in May 2019, prior to large clinical trials involving these PEGylated vaccines, Mohamed et. al. (2019) described a number of concerning findings regarding PEG and the immunological activation it had been shown to produce, which includes humoral, cell-mediated, and complement-based activation. They note that, paradoxically, large injection doses of PEG cause no apparent allergic reaction. Small doses, though, can lead to dramatic pathological immune activation. Vaccines employing PEGylation utilize micromolar amounts of these lipids, constituting this potentially immunogenic low-dose exposure. In animal studies it has been shown that complement activation is responsible for both anaphylaxis and cardiovascular collapse, and injected PEG activates multiple complement pathways in humans as well. The authors of one study conclude by noting that “This cascade of secondary mediators substantially amplifies effector immune responses and may induce anaphylaxis in sensitive individuals. Indeed, recent studies in pigs have demonstrated that systemic complement activation (e.g., induced following intravenous injection of PEGylated liposomes) can underlie cardiac anaphylaxis where C5a played a causal role.” (Hamad et al., 2008) It is also important to note that anaphylactoid shock in pigs occurred not with first injected exposure, but following second injected exposure (Kozma et al., 2019). The presence of antibodies against PEG is widespread in the population (Zhou et al., 2020). Yang and Lai (2015) found that around 42% of blood samples surveyed contained anti-PEG antibodies, and they warn that these could have important consequencesfor any PEG-based therapeutics introduced. Hong et. al. (2020) found anti-PEG antibodies with a prevalence up to 72% in populations with no prior exposure to PEG-based medical therapy. Lila et. al. (2018) note that the “existence of such anti-PEG antibodies has been intimately correlated with an impairment of therapeutic efficacy in tandem with the development of severe adverse effects in several clinical settings employing PEGylated-based therapeutics.” Anaphylaxis to vaccines has previously been assumedto be rare based on the frequency of such events reported to VAERS, a database established by the Centers for Disease Control and Prevention in 1990 for reporting of adverse events related to vaccines (Centers for Disease Control and Prevention, 1990; Su et al., 2019). While rare, anaphylaxis can be life-threatening, so it is important to monitor for the possibility in the short period following vaccination (McNeil et al., 2016).Sellaturay et. al., after reviewing 5 cases of anaphylaxis they link to PEG exposure, one near-fatal and involving cardiac arrest, write, “PEG is a high-risk ’hidden’ allergen, usually unsuspected and can cause frequent allergic reactions due to inadvertent re-exposure. Allergy investigation carries the risk International Journal of Vaccine Theory, Practice, and Research2(1), May 10, 2021 Page | 49of anaphylaxis and should be undertaken only in specialist drug allergy centres.” (Sellaturay et al., 2020). In fact it has already been demonstrated that pre-existing antibodies to PEG are linked to more common and more severe reactions upon re-exposure (Ganson et al., 2016). Is anaphylaxis upon exposure to PEG happening with a frequency relevant to public health? Numerous studies have now documented the phenomenon (Lee et al., 2015; Povsic et al., 2016; Wylon et al., 2016). Anaphylactic reactions to the mRNA vaccines are widely reported in the media (Kelso, 2021) and, as noted above, have been frequently reported in the VAERS database (690 reports of anaphylaxis following SARS-CoV-2 vaccines up to January 29, 2021). There are also some initial case studies published in the peer-reviewed literature (Garvey & Nasser, 2020; CDC COVID-19 Response Team, 2021, January 15). Anaphylaxis reactions to vaccines prior to these COVID-19 vaccines were generally reported at rates less than 2 cases per million vaccinations (McNeil et al., 2016), while the current rate with the COVID-19 vaccinations was reported by the CDC to be more than 11 cases per million (CDC COVID-19 Response Team, 2021, January 29). However, a published prospective study on 64,900 medical employees, where their reactions to their first mRNA vaccination were carefully monitored, found that 2.1% of the subjects reported acute allergic reactions. A more extreme reaction involving anaphylaxis occurred at a rate of 247 per million vaccinations (Blumenthal et al., 2021). This ismore than 21 times as many as were initially reported by the CDC. The second injection exposure is likely to cause even larger numbers of anaphylactic reactions
IV saline in bags manufactured by both Hospira and Baxter contained 1600-8000 microparticles/mL and 4-73 × 10⁶ nanoparticles/mL in solution. When IV immunoglobulin was diluted into the IV saline, 3700-23,000 microparticles/mL and 18-240 × 10⁶ nanoparticles/mL were detected. During processing of the solution through the IV system, in-line filters removed most microparticles. However, there were still 1-21 × 10⁶ nanoparticles/mL in IV saline and 7-83 × 10⁶ nanoparticles/mL in IV immunoglobulin diluted in saline.
"Intravenously injected nanomaterials can adsorb a wide range of proteins in the blood (39). The bio-corona of blood proteins is rapidly formed, and it has been shown to affect hemolysis and thrombocyte activation "
Remdesivir is a nitrile. More specifically, an altrononitrile. It is described by its IUPAC name: lalanine, N-((S)-hydroxyphenoxyphosphinyl)-, 2-ethylbutyl ester, 6-ester of 2-C-(4- aminopyrrolo(2,1-f)(1,2,4)triazin-7-yl)-2,5-anhydro-d-altronitrile.
Nitriles are very well known to chemists. They are very reactive molecules and very often toxic. They are used in the chemical industry to produce insecticides, pesticides, strong detergents to materials that are difficult to remove, such as metals.
Nitriles are cyanide compounds. This class of compounds is characterized by the presence of C≡N (cyan) and includes cyanides and nitriles (R-C≡N), as well as related compounds. chemical compounds such as cyanogens, isocyanates and cyanamides. They owe their
So my humble opinion is that the virus is just another burden, another oxidative stress. But, in most cases. it is not the cause of so called Covid" symptoms, injuries and deaths; toxicity/poisoning is.
HQC, Ivermectin, Vitamin D3, other antioxidants - anything what would prevent oxidative stress/poisoning - is a perfect treatment of C-19 but also to keep the vaccinated people alive, prevent their injuries, for as long as they need to detoxify.
After careful study of all those issues, my assessment is: This is not the virus that kills or injures, but whatever the people are poisoned with. It may also be 5 G radiation, as science proves that it also causes oxidative stress. And a flu is additional oxidative stress.
Nose-to-Brain Translocation and Cerebral Biodegradation of Thin Graphene Oxide Nanosheets
Highlights
Thin graphene oxide sheets can translocate from the nasal cavity to the brain
Translocation is size dependent, with ultrasmall nanometric sheets translocating the most
Kinetics of graphene oxide accumulation are time dependent and brain-region-specific
Brain-accumulated graphene oxide undergoes changes consistent with biodegradation
The nasal route represents a means by which nanomaterials can gain access to the brain in exposed individuals.14 Per the International Commission on Radiological Protection (ICRP) model of fractional depositions of inhaled particles,15 the aerodynamic diameter of an inhaled particle can influence its deposition in the pulmonary tract. Nanometer-sized particles are expected to deposit predominantly in the nasopharyngeal and laryngeal regions. Considering the anatomy of the olfactory region in the nose, which connects directly and indirectly with the brain,16 nanoparticle deposition in this region may result in nose-to-brain translocation. In support of this, epidemiologic studies, clinical trials, and animal experiments exploring the biodistribution of inhaled nanoparticles have identified the materials in extrapulmonary organs, including the brain.
Several modes of transport by which nanoparticles may enter the brain from the nasal cavities have been considered, including transport via axons of olfactory (olfactory neural pathway)31 and trigeminal (trigeminal pathway)32,33 neurons or via spaces between neuronal axons (paracellular transport).34 Other pathways include paracellular or transcellular transport in relation to olfactory sustentacular epithelial cells.16,35,36 Nanoparticles may also undergo absorption into the systemic circulation and then permeate the blood-brain barrier (BBB) to access the brain.16 The latter pathway remains unlikely due to various defenses of a healthy BBB, including efflux pumps and narrow tight junctions.37,38
How to Reach the Brain: G-Based Nanocarriers and the Blood-Brain Barrier
Common mechanisms of cytotoxicity of G nanosheets have been reported in literature on
different cell types, and include the physical interaction with cell membranes (Seabra et
al., 2014); disruption of cell cytoskeleton (Tian et al., 2017); oxidative stress due to
production of reactive oxygen species (ROS; Chen M. et al., 2016; Mittal et al., 2016);
mitochondrial damage (Pelin et al., 2017); DNA damage, such as chromosomal
fragmentation, DNA strand breakages, point mutations and oxidative DNA alterations
(Akhavan et al., 2012; Fahmi et al., 2017); autophagy (Chen et al., 2014); and apoptosis
and/or necrosis ... . It is clear, however, that G nanosheets may cause adverse environmental and health effects, leaving open the debate about their use as biomedical platform
Sona Nanotech is a nanotechnology life sciences firm that has developed multiple proprietary methods for the manufacture of various types of gold nanoparticles.
We are definitely playing Russian roulette with these toxic injections. From my observations, it seems that for many, if they don't die or get injured quite immediately, it takes from 5 months to about a year. Definitely one of the mechanisms of this nano-technology and peptides (proteins), in addition to inducing acute oxidative stress with all its effects, such as blood clotting, organ failure, strokes, heart failure, etc., is AMYLOID PLAQUE FORMATIONS in the presence of quantum dots. These self-assembling structures grow under the influence of certain factors, including temperature, UV light, ultrasound, PH, etc.
Thus, prevention and treatment tactics should be based on counteracting oxidative stress and disassembling these self-assembling peptide nano-semiconductors. My research shows that NAC (N-acetylcysteine) does this and all other antioxidants, including a diet rich in antioxidants would help achieve the goal. NAC doses should be high, at least initially.
These antioxidants and detox should be continued for as long as needed. Since these toxic components are deposited in the bone marrow, ovaries, spleen, etc. it can take a long time for one to eventually biodegrade these. So, people should have good amounts of life-saving antioxidants and research into this.
Sorry, but this is slaughter. We need to stop it.
This is "CORONA" and the reason why those "vaccines" are so coerced, forced, advertised - it has nothing to do with health, but everything to do with their greed and power trip:
Nano (NANO) formerly known as RaiBlockd is a decentralized and open-source cryptocurrency based on the direct acyclic graph (DAG) architecture. Using a block-lattice data structure, it operates without third parties.
Quantum dots are nanoparticles made up of semiconductor materials that transmit various colors when illuminated by light. This color depends on their dimension and the way they were produced. QMC has built a track and trace solution utilizing quantum dots and blockchain to confirm the creation of products and counterfeiting.
The authentication solution is blended with QDX HealthID for monitoring and tracking the mutinies of diseases, like the COVID-19. The solution validates individuals being tested, the persons conducting the test, and the test kits.
In more simplistic terms, QDX HealthID warrants that testing data is safe and not tampered with. Recently, health reports and medical certificates are being issued on paper, which makes them simple to forge.
“Not only does this service facilitate improved health outcomes for patients, but it also underpins back-to-work certifications, sometimes referred to as immunization passports,” said Stephen B. Squires, President & CEO of QMC in a statement.
With the health data supported by blockchain, governments and health agencies can form new plans and security measures to hold the spread of COVID-19 and other diseases. Additionally, individual users can evaluate their immunization passport, utilizing a mobile application. The app highlights color-coded indicators — yellow, green, and red. If the app displays the green indicator, the individual has the authorization to interact in social and work environments. This indicator can be bestowed and authenticated by others utilizing a QR code.
“The world must have a system that eliminates the fears and anxiety of not knowing who is able to return to work,” said Les Paull, CEO of QMVT, the unit responsible for sales and marketing of QMC’s innovations in a statement. The solution is hosted on the Microsoft Azure cloud and can combine with existing EMR systems. It is based on the Hyperledger Sawtooth enterprise blockchain, and for smart contracts, it’s applying the DAML (Digital Asset Modeling Language).
Wow, thank you for putting all this together. I had never heard of Internet of nano things. And I knew peg was toxic but I didn't know it's relationship to nanoparticles. Damn, this technology is so advanced, people have no idea. It will take me awhile to go through everything, but some of this are things I hadn't heard before.
I had lunch with a friend that I hadn't seen in over a year, triple injected. It turns out she's having worsening heart problems, she was totally healthy and active. Luckily she's open to it being myo or pericarditis, and we are in touch about detoxing.
https://www.instructables.com/Intelligent-Street-Light-Using-LoRa/ This prototype works on Master-slave configuration, where each street light acts as slave, and LoRa Gateway acts as the master. As Lora gateway has longer range compared to other communication services like wifi, Bluetooth, NFC etc.. Though GSM has the longer range it includes subscription charges which are not there is LoRa (Free of charge)and also LoRa consumes very less amount of power during operation. Master is connected to the internet so that user can remotely monitor street lights.So Large number of street lights can be connected and controlled from the Master gateway.
The Internet of Things (IoT) is a network of uniquely identifiable physical objects (things) which are internetworked to achieve control and information exchange via an information carrier based on standard communication protocols. IoT allows a wide variety of devices to create seamless communication and contextual interactions remotely across the existing network infrastructure. IoT enables all physical objects to act as uniquely addressable nodes and adds network functions to enhance and extend their main functionality. This feature introduces tremendous new capabilities and create a number of opportunities by providing controllable and even personalized interoperability and manageability in today's Smart City and Smart Energy Management Systems.
Adding IoT connectivity to street lights quantifies the benefits of sustainability development. The combination of network communicating, intelligent sensing, and sophisticated data analysis capabilities allow municipal authorities to monitor and dynamically control the street lighting systems. The IoT based lighting technology resolves the scalability challenges to manage a large number of streetlight facilities by aggregating and act on large amounts of data generated by IoT street lights to improve urban lighting services, maximize energy savings and reduce operation costs. As such, IoT networking technology creates a practical opportunity for more direct integration of LED street lighting into computer-based systems
The Internet of Things goes beyond powerful machine-to-machine (M2M) communications in street lighting management. A large number of applications can be put into practice within a broader context of the extensive development of smart city initiatives across the world. Smart street lighting systems can be implemented as a critical component in the smart city infrastructures and provide extended capabilities such as public safety monitoring, traffic management, weather monitoring, environmental protection, smart parking, WiFi accessing, Utility metering and leakage sensing, and voice broadcasting, etc. - or this" Mark Steele lives in the northern England town of Gateshead, which is a test site for these LED street lamps. He also claims to be a member of IEEE (the Institute of Electrical and Electronics Engineers) and is knowledgeable in what might be causing these strange maladies in Gateway. In his humble yet experienced opinion, the fine citizens of Gateway are being bombarded by 5G radiation emitted from the street lamps and the towers that control the wireless communications used to manipulate them. After noticing that his neighbors were reporting an unusual number of nosebleeds, cancer cases and worse, Steele believes it’s they that are being manipulated by the local government and businesses.“We are seeing babies dying in the womb as these transmitters are situated outside people’s bedroom windows. It’s a humanitarian crisis.” - Lighting experts say 5G is the future of street illumination. By equipping light poles with sensors and communications gear, cities can measure traffic, parking, noise, crowds, pollution, weather and other conditions and regulate the intensity of lighting on a schedule or on-the-fly. City officials love the idea because wireless communications eliminate the need for expensive digging, construction and repairs.If it weren’t for those pesky nosebleeds and birth defects.“Gateshead Council is NOT carrying out secret government trials in 5G technology via our street lights. We don’t know how these conspiracy stories start, but we are happy to report that this is exactly what these are. These tales are completely untrue and you should ignore them. Please be assured that there is no scientific basis or credible evidence for any of these scare stories about street lights causing cancer and other illnesses. We’ve taken advice from Public Health England who reviewed guidance issued by the World Health Organisation, the International Commission on Non-Ionizing Radiation and others, and they have confirmed that there is no risk.” The Gateshead Council denies it's using 5G and has been dealing with Steele and other protesters who originally started complaining that birds and flying insects began disappearing from their trees and yards soon after the towers and lights were installed. The protesters refer to people like Professor Ulrich Warnke, from the University of Saarland, who said in an interview with the Daily Mail that the EMF radiation from LED streetlights “causes disruption to the body’s nitrogen monoxide system, which keeps cells healthy and controls gene expression.” And they refer to the European Academy for Environmental Medicine, which says EMF radiation is linked to cancer and insomnia. etc. (https://mysteriousuniverse.org/2018/05/5g-streetlights-may-be-causing-mysterious-ailments/) Anyway, those lights are not normal, that's for sure and so many turned just purple UV light and surely this is harmful, but hidden behind the led light
daily 2000-3000 mg NAC, daily dose of Zinc 50 mg, Vitamin C 2000-3000, Quercetin 1500mg. You can add other antioxidants such as Resveratrol, Vitamin D3, Vitamin E, Q-10, etc
there are clays and baths and grounding and juicing but I've been using just supplements, they work - I sent it to someone else, I might have sent it, in case I paste it again, as this is a quintessence:
This would be a short summary : We are definitely playing a Russian roulette with those toxic injections. My observation is that for many, if they don't die or get injured quite immediately, it takes between 5 months to about one year. Definitely one of the mechanisms of this nano technology and peptides (proteins) in addition to just causing acute oxidative stress with all its outcomes, such as blood clotting, organ failure, strokes, heart failure, etc., is AMYLOID PLAQUE FORMATIONS in presence of quantum dots. Those self-assembling structures grow under the influence of certain factors including temperature, UV light, ultrasound, PH, etc.
So, the tactic of prevention and treatment should be to address oxidative stress and to disassemble those self-assembling peptide nano semiconductors. From my research it is clear NAC (N-acetylcysteine) does it and all other antioxidants, including antioxidant rich diet would help to reach the goal. NAC doses should be high, at least in the beginning.
Those antioxidants and detox should be continued for as long as it is needed. Since those toxic ingredients deposit in bone marrow, ovaries, spleen, etc., it may take a long time for one to eventually biodegrade those. So, people should have good amounts of life saving antioxidants and research in this direction.
Nice article. Much history is yet to surface, but I appreciate the ongoing depth examination of this complex story, uninhibited by a static point of view. You have proven to be free of said static point of view. I feel that commenting people need to be more cautious of the tales they believe in. Many are undoubtedly true enough to be said, some not so much. Literal demonstration of proof is always acceptable, otherwise it's point of view noise.
The ridiculous vaxxing of the creatures sickens me. Atrocious.
These people are insane. It's really the only explanation I can come up with, other than graft...
Hi Mathew,
Watching and listening now ... great choice for a guest to continue circling in on the 'dark triad' types who are running this scandemic — https://www.youtube.com/watch?v=gpjYtAB9i2w&t=35s.
Japan, where I live, is still pushing the PCR as if it were the gold standard.
It is frustrating how few Japanese remember, or were even informed, that former Tanzania President John Magufuli's health director found papaya, goats, and motor oil all had something in common. They tested positive for the virus according to the PCR test.
The big question — will enough socially pro-active people wake up to flip the dark tipping point aimed at us?
p.s. As of the last week of Aug., I had a chat with the surgeon who will be cutting a thyroid tumor from my throat next month. He mentioned that on the day of admission to the hospital, I will be given a PCR test, and if it comes up positive, everything is cancelled for at least 70 days. He could see I was smiling beneath my mask through the wrinkles at the corners of my eyes ... but to verify, I asked him how do the medical authorities know whether a PCR positive test is detecting a potentially infective virus, or the viral fragments after having caught and recovered from CoVid? 'Se desu ne!' he emphatically answered ... as if happy to find a patient who also realized the policy is nonsense. I have repeatedly been in close, sometimes physical contact with about 2,500 elementary and Jr. High school students for about a year and half now. If I haven't caught and recovered from the 'vid' by now, chances are I am not going to catch it. Still, the doctor said to reassure others, we must comply. Pretty much sums up the purpose of Japan's much vaunted preference of 'harmony' over 'human rights' ... not to mention its value over following the science.
Yes, I watched a bunch of Dr. Ramani's videos a few years ago when I was trying to understand some narcissists and borderline people I'd butted heads with over the years. She speaks with great clarity on the topics. I haven't watched her since, so I'd forgotten her name. I may find the right time to reach out to her when I'm focused on some aspect of the Kunlangeta and want a conversation partner to talk it through with who has all the detailed knowledge and deep experience that I don't (but do my best to intuit and research).
read a book a few years back called Ponerology: a science of evil for political purposes written by a professor in Canada. His theory included that our psychopaths are drawn to professions where they can do the most harm, and they will have the most control over others. Like Davos, or the NIAID .
Thanks for the heads up AJ. New book for me ... and intrigued, I found that it is free reading on my Kindle unlimited plan. I am moving this one higher in my to-read list, as I think it is hitting the psychological nail on the head behind the power shift.
Sounds like you already have a lot on your reading list, but you would appreciate https://ponerology.substack.com/?utm_source=substack&utm_medium=web&utm_campaign=substack_profile&utm_source=%2Fprofile%2F61362251-harrison-koehli&utm_medium=reader2
Wow. A new word for me, I didn't even realize there was a substack devoted to it.
Subscribed, with gratitude .... as grim though the subject may be.
Cheers Amking!
Wooowee! GREAT word for the day ... psychopaths even in peaceful communities. Yes. I am convinced that a combination of the dysfunctions of scale (maybe Gödel's Incompleteness Theorem is one great mathematical metaphor for it) and the salience of dark-triad personality traits and behavior is what has periodically lead to the great evil events of history ... and possibly the built-in, self-destruct button of our species.
You must be a new reader here:
https://www.campfire.wiki/doku.php?id=rounding_the_earth:the_kunlangeta
Hi again Mathew.
New AND sporadic.
I've been on Quora for 7 years, but it is only in the last few months I've started shifting to here and a few ''private'' groups. Igor Chudov, Batcattitude, Jestre, Steve Kirsch, Katherine Watt, Sage Hana, Tess Lawrie, Margarette Anna Alice, 2nd Smartest Guy, The Naked Emperor, etc. ... and that is just substack alone. Drowning in information, though getting a bit better at spotting and dismissing the b.s.
From what I've seen so far, your info is good stuff. It will take a while to work up my own ... but I've been in Japan at the fringes of academia for 40 years now, so will be be hoping for new readers myself.
One potentially useful and unique angle ... my 40 years of marginalization as a foreigner, overlapping with being an educational idealist and easy target for dark-triad personality types, and the general pattern of the collective identity of groups as having a high correlation with dark-triad personality types (MLK's Letter from a Birmingham Jail addresses that) ... all triangulate well with what is now happening world wide. Just a few years ago, my story, in the eyes of apologists for Japanese exceptionalism, would have been dismissed as the complaints of a loser. Now, my experience is a post-hoc fractal of what is happening to the average wage-slave.
Whaaat?! They vaccinated tigers and other animals? (are you kidding me?)
Whenever you think it can not get worse, they will surprise you with another action.
And soon we will see videos of Billy, Klausy, Tony and all their other friends running through the deserts with needles in their hands, trying to catch all lions and other animals in order to administer a lifesaving covid vaccine? Of course this is necessary, otherwise they can never reach "herd" immunity. And since there are so many lions and tigers hospitalized due to covid, it is absolutely necessary to vaccinate them. I always see lions lying on the street here due to covid (hundreds of lions per day) and being picked up by paramedics.
And please consider that one of these lions could -while chasing it- get too close to a zebra and infect it with the Sars-COV-2 Omicron variant. Poor zebra. How are we going to tell lions that they have to keep a distance of at least two meters while chasing and eating another animal? So all this shows you that we have to vaccinate them in order to reduce their risk by 95%. Maybe nearly 100%. The 95% are probably an underestimate.
How about insects? Can they get infected?
"Under laboratory conditions, house flies acquired and harbored infectious SARS-CoV-2 for up to 24 h post-exposure. In addition, house flies were able to mechanically transmit SARS-CoV-2 genomic RNA to the surrounding environment up to 24 h post-exposure."
https://parasitesandvectors.biomedcentral.com/articles/10.1186/s13071-021-04703-8
What about trees? Someone should study that. And rocks?
We already know smartphones can get infected and they can transmit.
I've often wondered if masks get infected and cause covid.
The trees! And if we eat the fruit from them or breathe in their pollen....what then?!!!! We're all gonna die!😉
Only if not vaxxed can you die. Or only if vaxxed. One or the other, not sure which. Maybe both.
We're doomed.😩
You will be safe if you wear a mask.
Maybe moreso with 2 or 3...indoors too. At home even. Sleeping too, especially for mouth breathers.
Fish literally have NO LUNGS and thus it is impossible for them to suffer from a respiratory disease like the flu/Covid-19/et al.
Also, if you want to learn more about vaccines in animals, look at South Korea. For a while there, they made it mandatory to have house pets tested AND vaccinated, plus they took the extra ridiculous step of putting cats who "tested positive" in "quarantine centers". Beyond ridiculous.
We'll have to vax every rat, cat, bat, gnat, and sea cucumber at exactly the same time so that covid doesn't mutate again.... but it will be worth it since Pfizer Moderna will make so many billions!!!
😂
Anecdotal, I know, but all 4 humans in my household got Omicron about 2 months ago but neither of our pets got sick during that time and were definitely exposed (house rabbit and puppy) . My puppy wanted to lie next to me in bed when I was sick so was in very close contact.
Compared with humans, most animals (including dogs) produce their own vitamin C. When they are sick or stressed (and probably also when they are exposed to pathogens), they produce a much higher amount (10 times higher than normal). For example, when sick, a goat that weighs 70 kg may produce up to 100 Grams of Vitamin C per day. Compare this with the <100 mg of vitamin C that most people eat per day.
This might be one of the reasons why many animals are more resistant. I could imagine other reasons as well. Probably another bacterial composition in their oropharynx, in their gut etc... They need a much stronger "microbiota" which defends them because, for example, carnivores eat raw meat which contains pathogens... So they probably have a better defense against several pathogens than humans.
I had a horrid case of delta, while on vacation with my 3yr old granddaughter. We shared a bed and a bedroom, she never even sneezed. 2 cats in the house were never taken by ambulance to the emergency vet. I wish I had been that lucky.
Re: The Hydrogel patent US8415325B2 is listed in the Moderna patent, here. Official Biochemical and Statistical Evidence 100% confirms Moderna created Covid-19 patented in 2013
Covid-19 means: 19 nucleotide sequence and not 2019 at all.
By The Exposé on March 3, 2022
Evidence has emerged which proves beyond a reasonable doubt that the pharmaceutical giant Moderna, the company that has made billions through the sale of an experimental Covid-19 injection, actually created the Covid-19 virus.
They cited a Paper by Scientists in India, Switzerland, Italy and the US (cautiously entitled: MSH3 Homology and Potential Recombination Link to SARS-CoV-2 Furin Cleavage Site) in which they calculated that the chances of a 19 nucleotide sequence patented by Moderna randomly appearing in Covid-19 in circumstances where it does not appear anywhere else in nature are 1 in 3 trillion.
Furthermore they did not merely apply for a patent on 2016 February 4 with US9587003B2: as reported in the Daily Mail. They actually applied on 2013 December 16 for 4 patents with US9149506B2, US9216205B2, US9255129B2, US9301993B2:as well.
So Moderna had developed the 19 nucleotide gene sequence containing the Furin Cleavage Site which gives Covid19 its infectivity to humans by patented gain of function research as early as 2013, 6 years before the Wuhan outbreak took place. Not 3 as reported in the Mail and virally elsewhere..
Covid-19 was not made in 2019. It was made from the 19 nucleotide Moderna specific chimeric (CGG for AGA) furin cleavage site (in 2013) which does not occur anywhere in nature. And every Covid death and every Covid vaccine death is parked squarely on the doorstep of ModeRNA and The Covid19 makers, the genetic vaccine makers. their funders and their promoters, which include almost every government and public sector and health service in the world, are therefore guilty of Genocide and crimes against humanity. They have pushed genetic rape and sickness and death onto half of the population of the world in order to enrich the pockets of Pharmaceutical Companies. Governments and Public sectors around the world have abandoned their health service regulation to billionaires and heartless corporations (me: and to make we humans, Trans Humans and now, the vaccinated, without any human rights whatsoever
The Expose
2) Dr Ugur Sahin, the COVID-19 vaccine he designed for Pfizer was designed in just few hours in a single day (on a computer) on January 25, 2020. No other vaccine in history has been created and manufactured so quickly. Previously, the fastest vaccine ever developed took more than four years. co-founder of BioNTech Not only that, Pfizer Chairman (((Albert Bourla))) hasn’t gotten around to having his shot, or Dr Ugur Sahin, last I knew. And it went from laboratory straight into human arms without any animal testing first - mRNA never used in humans ever before - doesn't that strike you as odd?
Obviously, no virus was present, when this vaccine was made on a computer and a Covid infection, was not the basis of the vaccine creation, in the first place.
Documents by Pfizer Show BioNTech Paid FDA $2,875,842.00 "Drug User Fee" for COVID-19 Vaccine Approval
Vaccine Impact
3) The Hydrogel patent US8415325B2 is listed in the Moderna patent, here. Hydrogels are also mentioned in a second Moderna patent, here. Hydrogel is listed in the Johnson & Johnson patent, here. Hydrogels are made from Graphene Oxide. Nobody can deny the evidence that Graphene Oxide is in the shots.
https://thecovidblog.com/2022/01/17/are-covid-19-injections-the-ethno-bomb-israel-began-developing-in-the-late-1990s/
"The “smoking gun” if you will is CTCCTCGGCGGGCACGTAG. That is the 19 nucleotide genome sequence of SARS-CoV-2. The chances of this sequence happening in nature are less than one in a billion. There was no such virus containing this sequence prior to 2020. Every patent in BLAST that contains this near-impossible sequence is owned by Moderna, and all of them predate SARS-CoV-2.
Dr. Michael Worobey is the Head of Ecology and Evolutionary Biology at the University of Arizona. He attempted to prove that SARS-CoV-2 is a product of nature. “Dr. Syed” responded and completely dismantled Dr. Worobey arguments in one tweet. The latter disappeared and did not respond further."
The most deadly outbreaks affected very specific ethic groups. Why, for the vast majority, did it present as a common cold?
"COVID-19 - A Biological Weapon Targeting Ethnicity and Body Systems" By Larry Romanoff https://www.moonofshanghai.com/2022/03/en-larry-romanoff-covid-19-biological.html
Oh my gosh, I just remembered when Denmark slaughtered thousands of mink because they supposedly had Covid-19, and then they "came back to life" when their graves started bouncing up and down. Friggin' nightmare fuel.
https://www.zerohedge.com/covid-19/la-public-health-department-faces-backlash-after-offering-covid-19-test-animals-including
They don't even pretend to be serious.
It must have been climate change that killed those tigers? Or maybe they were doing too much gardening, or baking apple pies?
"The reason no animals tested positive for Covid in 2020," said Ja Beded, but then Ja keeled over dead. Another case of so, so SADS. Local doctors speculated his death was due his not having received his seventh booster until 3mths and 2 full days after the 6th.
Re social engineering using "conservation NGOs" -- like Daszak's Eco Health Alliance?
From Wikipedia:
Founded under the name Wildlife Preservation Trust International in 1971 by British naturalist, author, and television personality Gerald Durrell, it became The Wildlife Trust in 1999. In the fall of 2010, the organization changed its name to EcoHealth Alliance. The rebrand reflected a change in the organization's focus, moving from solely a conservation nonprofit which focused mainly on the captive breeding of endangered species, to an environmental health organization with its foundation in conservation.
Appears so if you copy pasted well.
Most tragic to have drop shots administered to the innocent animals.
Vaccinating animals? Tigers? How much worse can this get? Here I thought we were finally getting the truth out about vax injuries and possibly rounding a corner. CDC admitting what many have known for 2 years. But now we learn about animals and going back way before we thought it started. Utter nightmare.
Shocking images: https://anamihalceamdphd.substack.com/p/computerized-thermographic-imaging?utm_source=substack&utm_medium=email - https://rumble.com/v1gzhzh-computerized-thermographic-imaging-and-live-blood-analysis-post-c19-injecti.html
Thanks. This was a good interview, and the thermographic images showing the large blood clots is another proof along with the embalmers. So sad though.
My experience is with NAC other antioxidants - Precursors of glutathione reverse blood clots and prevent and reverse the aggregation of amyloid plaque formations
There is science behind, if you're interested. Thank you for your comment
Yes, I'm interested in the science behind it.
PEG - 6
Toxicity and immunogenicity concerns related to PEGylated-micelle carrier systems: a review - PMC (nih.gov) Sci Technol Adv Mater. 2019; 20(1): 324–336.
Published online 2019 Apr 15. doi: 10.1080/14686996.2019.1590126
In vivo Studies on Pharmacokinetics, Toxicity and Immunogenicity of Po | IJN (dovepress.com)
However, it should be emphasized that long-lasting elevated levels of cytokines can lead to inflammation-mediated toxicity.46,47 For example, high levels of GM-CSF, IFN-γ, IL-23, IL-6, and IL-17α were suggested to be involved in the development of organ-related autoimmune inflammatory diseases.48
Etc.
It is an unbelievable crime over something what for most people is completely not lethal, especially with the right treatment
PEG - 5
PEGylation and anti-PEG antibodies - ScienceDirect
Abstract
Polyethylene glycol (PEG) is generally considered a stealth polymer that is universally used to extend the circulation times and enhance the therapeutic efficacy of nanocarrier-based and/or protein therapeutics. Nonetheless, in contrast to the general concept that PEG is nonimmunogenic, a growing body of literature has emerged declaring PEG to be immunogenic, which is manifested by the robust production of anti-PEG antibodies. The existence of such anti-PEG antibodies has been intimately correlated with an impairment of therapeutic efficacy in tandem with the development of severe adverse effects in several clinical settings employing PEGylated-based therapeutics. This chapter is a discussion of the mechanisms beyond anti-PEG immunity as well as the implications that preexisting and treatment-induced anti-PEG antibodies is exerting on the fate of PEGylated products. In addition, several alternative technologies beyond PEGylation are highlighted.
Full article: PEGylated liposomes: immunological responses (tandfonline.com)
ABSTRACT
A commonly held view is that nanocarriers conjugated to polyethylene glycol (PEG) are non-immunogenic. However, many studies have reported that unexpected immune responses have occurred against PEG-conjugated nanocarriers. One unanticipated response is the rapid clearance of PEGylated nanocarriers upon repeat administration, called the accelerated blood clearance (ABC) phenomenon. ABC involves the production of antibodies toward nanocarrier components, including PEG, which reduces the safety and effectiveness of encapsulated therapeutic agents. Another immune response is the hypersensitivity or infusion reaction referred to as complement (C) activation-related pseudoallergy (CARPA). Such immunogenicity and adverse reactivities of PEGylated nanocarriers may be of potential concern for the clinical use of PEGylated therapeutics. Accordingly, screening of the immunogenicity and CARPA reactogenicity of nanocarrier-based therapeutics should be a prerequisite before they can proceed into clinical studies. This review presents PEGylated liposomes, immunogenicity of PEG, the ABC phenomenon, C activation and lipid-induced CARPA from a toxicological point of view, and also addresses the factors that influence these adverse interactions with the immune system. (...)
The presence of pre-existing anti-PEG antibodies might trigger further immunogenic responses to PEG when the human subjects receive PEGylated therapeutics [25,26]. These pre-existing and induced anti-PEG antibodies together may compromise the response to PEGylated medicines in the clinical settings [29–31]. (...)
4.1 Mechanism of the ABC phenomenon
According to Dams et al. [39], in animal models, a second dose of PEGylated liposomes, injected within a time interval of 5 and 21 days, was cleared very rapidly from the blood circulation. The ABC phenomenon showed two distinct phases: the induction phase and the effectuation phase. The induction phase followed the initial dose of PEGylated liposomes in which the biological system is ‘primed’. The effectuation phase occurs at day 3–7 after the initial dose in which a subsequent dose of PEGylated liposomes is rapidly cleared from systemic circulation [42]. (...)
5.2.4 Route and speed of intravenous administration
The intensity of the pulmonary hypertension is influenced by the route and rate of administration. It has been reported that administration of SUV in pigs by slow infusion suppressed the pulmonary hypertensive effect, compared to the effect observed with bolus intravenous injections [94]. These results can be accounted for by the elevation of blood anaphylatoxins levels, which are considered the rate limiting mediator in pulmonary vasoactivity [103]. Studies showed that the steady-state level of functional anaphylatoxins is controlled by the production rate and clearance rate of C3a and C5a in the plasma. Since the clearance rate is unaffected by the method of administration, anaphylatoxins levels in the blood would be proportional to the degree of complement activation induced by the injected liposomes, as well as the speed of liposome injection.
6. Toxicity relating to ABC phenomenon and CARPA
A few researchers have reported that repeated injection of empty PEGylated liposomes altered their pharmacokinetic behavior (the ABC phenomenon), which might lead to lower therapeutic efficacy and even unexpected side effects, if cytotoxic drugs were encapsulated [58,72,73]. In other than liposomes, it has been reported that repeated injections of long circulating organic-inorganic hybrid nanoparticles induced the ABC phenomenon, which substantially attenuated the passive targeting of 64Cu-labeled PEGylated nanoparticles in a murine model of peripheral arterial disease [105]. In addition, the PEGylated liposomal formulations including Doxil®, Ambisome®, Abelect®, and Amphocyl® showed acute immune toxicity represented in non-IgE mediated hypersensitivity reactions (CARPA) in a small percentage of individuals treated for the first time in the absence of pre-medication [21,75,94].
PEG - 4
These findings and explanations taken together support the proposal that the binding of anti-PEG IgM to Doxebo/Doxil in blood explains complement activation, which entails anaphylatoxin production and opsonization of liposomes.
Mechanism of HSR to PEGylated Nanomedicines: Piecing the Steps Together
On the basis of a long list of evidence for a causal role of complement activation in certain liposome-induced HSRs (Supplement Table 1) we proposed earlier that CARPA represents a major mechanism of infusion reactions to a variety of nanoparticulate drugs and agents. (21,22) However, recently, the role of complement in infusion reactions has been questioned (23) on the basis of an experiment that showed no complement activation by a polystyrene nanoparticle in pig blood in vitro, although it caused pulmonary reactions in pigs in vivo. (24) Although the validity of these in vitro data and the generalization of conclusions was debated, (25,26) the ultimate question, what is the contribution of complement activation to nanoparticle-induced cardiopulmonary distress of pigs vis-à-vis other mechanisms, remained open. (...)
Our present data showing significant correlation between pulmonary hypertension and rise of sC5b-9 in the blood of animals sensitized for Ab-mediated C activation represent direct evidence that complement activation can play a causal role in the pigs’ cardiopulmonary distress. In addition, the acceleration of cardiovascular distress to pseudo-anaphylaxis in immunized animals displaying high anti-PEG IgM titer in blood, taken together with the increased C3 conversion by Doxil in immune vs naı̈ve pig serum and the accelerated clearance of anti-PEG IgM on the same time course as complement activation and the cardiopulmonary reaction proceeds, suggests a causal relationship not only between C activation and pulmonary reaction but also between anti-PEG IgM levels in blood and complement activation. These processes pieced together suggest the comprehensive reaction scheme in Figure 7, illustrating the sequence of reaction steps along an immuno-circulatory axis: first the binding of Abs to liposomes causing complement activation, liberation of anaphylatoxins and other complement cleavage products, and their stimulatory effects on allergy-mediating innate immune cells entailing the secretion of vasoactive and inflammatory mediators, which are responsible for the symptoms of HSRs. (...)
The Concept of “Primary ABC”
In ABC, studied for nearly two decades mainly in murine models, (30−35) the rapid clearance of liposomes has been attributed to the binding of anti-PEG IgM to the vesicles, entailing complement activation, opsonization, and rapid clearance by the MPS. These anti-PEG Abs were shown to be formed in splenic marginal zone B cells via T-cell independent immunization by a prior injection of PEGylated liposomes. (32−35) It is therefore a fundamental difference between the above “classical” ABC and our observations on rapid anti-PEG IgM clearance that the latter process occurs already after the first injection of liposomes; there is no priming (Figure 2B and C). Assuming that the anti-PEG IgM undergoing rapid clearance was liposome-bound, the finding suggests that preexisting, naturally occurring anti-PEG IgM can similarly remove liposomes as the induced Abs in “classical” ABC. Thus, the rapid decay of anti-PEG IgM shown in Figure 2B and C may reflect “primary” ABC with many of the attributes of “secondary” ABC. Accordingly, primary ABC and CARPA may represent “two sides of the same coin”, (35) raising the question of why HSR was never reported during secondary ABC in rats and mice. The most likely explanation is that these species have orders of magnitude lower sensitivity for HSRs than pigs or hypersensitive human. (29,36) It is the high sensitivity of the pig model for HSRs that enabled uncovering of this duality.
Criticism of the Porcine Model
The pig model used in this study has recently been claimed to be irrelevant to the average human patient and is therefore misleading for assessing the risk of nanomedicine-induced HSRs. (23,39−41) The reasons for this view included the difference of HSR rate in pigs and the average human, different underlying immune mechanisms, and the “globality” of cardiopulmonary reactions. To clarify possible misunderstandings that led to the above conclusions, it seems important to re-emphasize (18,19,25) that the pig model is not a traditional immune toxicology model where the toxicities of drugs on the immune system are assessed in healthy animals to predict possible adverse immune effects in immunologically normal humans. Like other animal models of allergy, the pig model is an allergic disease model, i.e., that of severe hypersensitivity of a small percentage of people to certain i.v. administered nanopharmaceuticals. Regardless of the underlying mechanism, the concordance with human symptoms (see below) enables the model to serve for identifying the hazard of hypersensitivity reaction to the tested drug in the case of hypersensitive patients. Also, certain cardiopulmonary and other physiological changes are quantitative and highly reproducible within the dynamic window of the test, where the adverse response is dose dependent. This allows using the model for the assessment of the risk that the tested drugs might cause HSR, to study the mechanism of these reactions and develop methods for their prevention.
Clinical Relevance of the Porcine CARPA Model
In keeping with the above claims on human relevance, our observations in the pig model show significant concordance with some recent clinical trial data. Namely, the “RADAR” and “REGULATE-PCI” trials with pegnivacogin (Revolixys kit) (42,43) were stopped because of life-threatening HSRs. The tested PEGylated aptamer caused anaphylaxis in 3/640 (0.46%) and 10/1605 (0.62%) patients, and reactions were observed exclusively in those who had high levels of preformed anti-PEG antibodies. (42,43) Importantly, the indications of complement activation (rises of C3a, Bb, drop of CH50) included C4d, a biomarker of classical pathway complement activation. (42,43) In agreement with the conclusion in the present study, the authors of the above-mentioned clinical study suggested anti-PEG Ab-triggered complement activation (i.e., CARPA) as the underlying cause of anaphylactic reactions, although they assign the reactions to anti-PEG IgG, rather than anti-PEG IgM (which was not measured). In another clinical study on the frequent and severe HSRs to pegloticase (Krystexxa), a PEGylated recombinant porcine enzyme (uricase) used for the treatment of refractory gout, the HSRs were shown to be correlated with the preexisting and induced anti-PEG Abs and rapid loss of the drug’s efficacy. (14,44) Yet another testimony to the clinical relevance of the pig model is the recent FDA approval of a transthyretin-directed small inhibitory RNA-containing nanoparticle (patisiran, Onpattro), whose safe administration protocol was developed, in part, using the porcine CARPA model. (45)
Perspective
This study provided experimental support for the concept that PEGylated liposome-induced CARPA, whose worst manifestation is pseudo-anaphylactic shock, proceeds along the complement–circulatory system axis, via acute cascadic activation of innate humoral and cellular immunity. This information may help to better understand and, hence, more efficiently predict and prevent HSRs to PEGylated and other nanopharmaceuticals. Furthermore, the listed evidence of concordance between the physiological and immune responses to PEGylated nanoparticles in pigs and humans, as well as the example of using the model by the biopharma industry, provides strong support for the human relevance and use of the porcine CARPA model for hazard identification in preclinical safety studies.
PEG - 3
Polyethylene glycol (PEG)-coated nanopharmaceuticals can cause mild to severe hypersensitivity reactions (HSRs), which can occasionally be life threatening or even lethal. The phenomenon represents an unsolved immune barrier to the use of these drugs, yet its mechanism is poorly understood. This study showed that a single i.v. injection in pigs of a low dose of PEGylated liposomes (Doxebo) induced a massive rise of anti-PEG IgM in blood, peaking at days 7–9 and declining over 6 weeks. Bolus injections of PEG-liposomes during seroconversion resulted in anaphylactoid shock (pseudo-anaphylaxis) within 2–3 min, although similar treatments of naı̈ve animals led to only mild hemodynamic disturbance. Parallel measurement of pulmonary arterial pressure (PAP) and sC5b-9 in blood, taken as measures of HSR and complement activation, respectively, showed a concordant rise of the two variables within 3 min and a decline within 15 min, suggesting a causal relationship between complement activation and pulmonary hypertension. We also observed a rapid decline of anti-PEG IgM in the blood within minutes, increased binding of PEGylated liposomes to IgM+ B cells in the spleen of immunized animals compared to control, and increased C3 conversion by PEGylated liposomes in the serum of immunized pigs. These observations taken together suggest rapid binding of anti-PEG IgM to PEGylated liposomes, leading to complement activation via the classical pathway, entailing anaphylactoid shock and accelerated blood clearance of liposome–IgM complexes. These data suggest that complement activation plays a causal role in severe HSRs to PEGylated nanomedicines and that pigs can be used as a hazard identification model to assess the risk of HSRs in preclinical safety studies.
An unresolved issue with such PEGylated nanopharmaceuticals is their recognition by the immune system manifested in non-IgE-mediated (pseudoallergic) hypersensitivity reactions (HSRs), an adverse event commonly called infusion reaction. (1−7) PEGylated nanomedicines that have been reported to cause such reactions include PEGylated liposomal doxorubicin (Doxil/Caelyx), (8) PEGylated G-CSF (pegfilgrastim, Neulasta), (9) PEGylated erythropoetin (mono-mPEG-epoetin-β, Mircera), (10) PEGylated recombinant human factor VIII (Adynovate), (11) and PEGylated phenylalanine ammonia lyase (pegvaliase-pqpz, Palynziq), (12) with at least three formulations withdrawn from clinical use partly because of severe HSRs: PEGylated EPO-mimetic peptide (peginesatide, Omontys), (13) PEGylated urate oxidase (pegloticase, Krystexxa), (14) and a PEGylated IXa blocker RNA aptamer (pegnivacogin, Revolixys). (15)
The symptoms include shortness of breath, facial redness and swelling, chest pain, back pain, flashing, rash, chills, panic, and fever that mostly arise shortly after the first treatment, although reactions starting later or after repeated treatments are also observed. In most cases the problem spontaneously resolves or can easily be controlled; however, occasionally, the reaction can escalate into pseudo-anaphylaxis, a severe, occasionally lethal form of infusion reactions resembling anaphylaxis without IgE playing a role. It is also known as anaphylactoid reaction, or anaphylactoid shock.
In order to better understand these reactions and help their prediction and prevention, the present study used the porcine complement activation-related pseudoallergy (CARPA) model, (16−19) which was shown previously to display typical symptoms of cardiac anaphylaxis, (16) whereupon the cause of sudden death is shock with cardiac arrest. We used the model for uncovering the immune mechanism underlying the HSRs to PEGylated drugs, taking PEGylated liposomal doxorubicin (Doxil/Caelyx) and its drug-free formulation, placebo Doxil (Doxebo) (20) as model agents. By providing evidence for a causal relationship among the induction of anti-PEG antibodies, complement activation, and pseudo-anaphylaxis, the present data highlight the mechanism of Doxil-induced severe HSRs and use of the pig model in understanding and predicting this type of immune toxicity of PEGylated nanopharmaceuticals. (...)
A single i.v. treatment of pigs with low (0.1 mg phospholipid (PL)/kg) Doxebo led to a massive rise of anti-PEG IgM and a parallel smaller rise of anti-PEG IgG antibodies (Abs) (Figure 1). Panels A and B show the titers on linear and logarithmic scales, respectively, the latter amplifying the lower region of titer changes. The rise of Abs started on day 3 following treatment, and the titers reached a peak between days 7–9 and returned to close to baseline after 4–6 weeks. Essentially similar, although less expressed titers were obtained when whole Doxebo was used as antigen in the ELISA (...)
Amplified Reactogenicity of PEGylated Liposomes in Pigs Immunized with Doxebo
If anti-PEG IgM plays a causal role in Doxil-induced HSRs, as suggested by the data in Figure 2, intentional elevation of these Abs by way of immunization with Doxebo (Figure 1) is expected to increase the reactogenicity of PEGylated liposomes. The experiments shown in Figure 3 proved this prediction with unexpected power. Bolus injections of Doxebo and Doxil in 5 immunized pigs led within 2 min to life-threatening HSR in one and lethal pseudo-anaphylaxis requiring resuscitation in 4 animals, regardless of the timing of the test within the 2–6-week window of seroconversion.
As illustrated with the surviving animal in Figure 3A, the PAP considerably increased in both amplitude and duration compared to that seen in naı̈ve animals (Figure 2A), and we observed significant SAP and heart rate (HR) changes even after repeated injections of liposomes (Figure 3A). This implies loss of tachyphylaxis (self-tolerance), which is a characteristic feature of Doxil reactions in naı̈ve pigs and is thought to be due to depletion of natural antibodies, (20) for which we obtained evidence in Figure 2B and C. Thus, the consumption of reactive antibodies during the first reaction was not enough to deplete them to nonreactive levels. Figure 3B illustrates the deadly pseudoanaphylaxis with maximal rise of PAP and shock developing within 2 min. The panel also illustrates the moments of resuscitation with cardiac massage and epinephrine, resulting in an overshot of SAP. Figure 3C shows that these severe reactions were associated with extensive flushing and rash within 3 min.
Figure 3. Reactogenicity of PEGylated liposomes in pigs immunized with Doxebo. (A) Hemodynamic changes in one out of 5 animals, showing severe but not lethal responses to repetitive injections of the specified liposome doses 4 weeks after immunization. (B) pseudo-anaphylactic shock in another pig illustrating the reaction of 4 out of 5 immunized pigs tested in the 2–6-week interval after immunization. In real-time hemodynamic tracings, the large-amplitude noise coincided with cardiac massage. (C) Abdominal region of the skin before (“control”) and 3 min after the injection of Doxebo, showing confluent skin flushing and rash observed in all 5 pigs. The objects in the pictures include a three-way stopcock connected to a pressure transducer and the syringe used to inflate the spinnaker balloon of the Swan-Ganz catheter (see Materials and Methods).
Regarding the dose–effect relationship between anti-PEG IgM and HSRs in immunized pigs, apart from the need or no need for resuscitation, the reactions were quantitatively indistinguishable regardless of the actual—significantly elevated—titers of anti-PEG IgM at the time of the experiment. This suggests that the significant correlation between anti-PEG IgM and HSR obtained for naı̈ve animals (Figure 2D) is not applicable in immunized pigs, as the amount of anti-PEG IgM in blood far exceeds the plateau of the dynamic range of dose–effect relationship, whose exact limits remain to be determined.
The data in Figure 3 reveal effective sensitization of animals for PEGylated liposome-induced HSRs by immunization-induced rise of anti-PEG IgM, which is consistent with a causal role of these Abs in the phenomenon. As for the exact mechanism of the cause–effect relationship, considering that antigen-bound IgM is one of the most powerful activators of the complement system via the classical pathway, and that there is a large body of evidence for the CARPA theory, i.e., that complement activation plays a causal role in many HSRs (Supporting Table 1), complement activation represents an obvious link between anti-PEG IgM and HSR. However, such a link has had only indirect experimental support to date, and the elevation of complement activation byproducts in pig blood during HSRs has never been shown. (16−21) (...)
Continuation of PEG subject:
Anaphylaxis to the first COVID-19 vaccine: is polyethylene glycol (PEG) the culprit? - British Journal of Anaesthesia (bjanaesthesia.org)
The COVID-19 vaccine from Pfizer–BioNTech recently introduced in the UK, USA, and other countries is a messenger RNA (mRNA)-based vaccine (tozinameran, BNT-162b2) using lipid nanoparticles to facilitate the transport of mRNA into cells.
The vaccine contains a number of excipients and lipids, one of them based on PEG-2000. This is currently the only excipient in the vaccine with recognised allergenic potential. The severity and rapid onset of the two reported reactions to the vaccine further increase suspicion towards PEG.
Allergy to excipients is often overlooked because of a lack of knowledge about their allergenic potential. However, allergy to PEG, also often called macrogol, has been reported with increasing frequency over recent years,
Patients have usually had repeated systemic allergic reactions/anaphylaxis before diagnosis. (...)
The mechanism of sensitisation to PEGs is unknown, but from the cases described in the literature and our personal experience with a total of 18 patients with PEG allergy, there is no reason to believe that existing inhalational or food allergies predispose to PEG allergy. However, PEG allergy may be suspected in patients with very severe reactions to drugs where the cause is unconfirmed, or patients with repeated immediate-type reactions to several structurally unrelated drugs or other products containing PEG.
Exclusion criteria for the clinical trials of the vaccine included individuals with known hypersensitivity to vaccines, or with a history of allergy, hypersensitivity, or intolerance to the COVID-19 vaccine or its excipients according to the registration of the trials on ClinicalTrials.gov. At the FDA advisory committee meeting, the cases of anaphylaxis in the UK were discussed at length. The advisory committee voted 17 to 4 in favour of granting Pfizer emergency approval for the vaccine, which was granted on December 11, 2020. The FDA requested that a warning be added to the product information that medication to treat immediate-type hypersensitivity reactions should be available where vaccinations take place. Also, the FDA advised that the vaccine should be contraindicated in patients with a severe allergic reaction to the first dose of vaccine, or with known hypersensitivity to any ingredient/component of the vaccine. Finally, a stringent surveillance system is to be initiated to monitor adverse effects of the vaccine with monthly reporting.
The individuals who have had allergic reactions to the vaccine in the UK should be urgently investigated to determine the mechanisms behind the reactions and the potential involvement of PEG. The reported history of previous severe allergies should be scrutinised and their causes determined.
Investigations for allergy to PEG currently include skin testing,but in vitro tests may be in the pipeline.
As systemic allergic reactions have been reported in connection with skin prick testing in PEG-allergic patients, the development of a reliable in vitro test is urgently needed.
PEG has not been used previously as an excipient in vaccines with this potential for wide dissemination, but even if PEG is concluded to be the cause, allergy to this excipient is also very rare. As soon as a plausible explanation for the suspected vaccine reactions has been found, clear recommendations can be made for a safe vaccination strategy.
Pseudo-anaphylaxis to Polyethylene Glycol (PEG)-Coated Liposomes: Roles of Anti-PEG IgM and Complement Activation in a Porcine Model of Human Infusion Reactions | ACS Nano
PEG on its own is another huge topic regarding its toxicity and ability to sensitize people (Polyethylene Glycol) as a novel technology and the issue of sensitizing recipients and allergy/severe adverse reaction
In connection with PGE - where are the studies??? Because, as demonstrated below, we are taking entire humanity on a totally unknown path.
Are we going to let this experiment to continue on the entire human race?
We are on the level of 3rd and 4th booster (even 5th) - but even Fauci says they do not know if 3rd booster is enough, or 4th, or what else, after, while Minister "of Health" of Canada claims we needto have a "booster" every 9 months!. Because simply it was not possible to do more testing because of the time issue. So we are conducting phase 3 on the humanity, and we are offering endless boosting with literally NO existing data and even further testing!
So I want to also add to this the fact, that using just Polyethylene Glycol is HIGHLY questionable. We already have allergy to it. Sensitizing people, create even more danger. So what about additional doses and PEG?
So how is this possible those regulators, vaccine companies, governments are dragging the entire humanity, including children and pregnant into such an unchartered territory?
Where is the real risk/benefit scenario, if we do not know what comes after the 5th, 6th etc. boosters, or even 4th one, if simply the experiment is not reaching so far? Let's just look into future: Does Pfizer, or FDA or anyone know? How many boosters we are going to be given? Australia bought 10-14? Why? Where is the science? Are we all lab rats?
Questions regarding JUST PEG:
1. How many more boosters is needed?
2. How many our immune system can handle?
3. What about sensitizing people with more PEG?
4. WHERE IS EVALUATION of ADVERSE REACTIONS in regards to possible adverse reactions from PGE (autoimmune problems, allergies, etc.)?
So, when FDA took the decision on injecting the people, they also said this will be monitored. Is it? Is there an active group of scientists evaluating it?
There is no evaluation, nothing, no real science behind, no plan and safety data for anyone in longer term. Why do we need to agree on such an experiment, or be coerced or forced?
Now they can just inject new "boosters" without ANY studies.
Even, just for PEG sensitivity question level:
View of Worse Than the Disease? Reviewing Some Possible Unintended Consequences of the mRNA Vaccines Against COVID-19 (ijvtpr.com)
Adjuvants, Polyethylene Glycol, and AnaphylaxisAdjuvants are vaccine additives intended to “elicit distinctive immunological profiles with regard to the direction, duration, and strength of immune responses” from the vaccines to which they are added (Liang et al., 2020). Alum or other aluminum compounds are most commonly utilized in traditional vaccines, and they elicit a wide range of systemic immune activation pathways as well as stromal cell activation at the site of the injection (Lambrecht et al., 2009; Danielsson & Eriksson, 2021).An aluminum-based adjuvant was determined not to be optimal for a coronavirus vaccine, so other solutions were sought (Liang et. al., 2020). A solution presented itself in the form of the widely used pharmaceutical ingredient polyethylene glycol, or PEG. A limiting factor in the use of nucleic-acid-based vaccines is the tendency for the nucleic acids to be quickly degraded by nuclease enzymes (Ho et al., 2021). Regarding the RNAse enzymes targeting injected mRNA, these enzymes are widely distributed both intracellularly (primarily within the lysosomes) (Fujiwara et al., 2017) and extracellularly (Lu et al., 2018). To overcome this limitation, both mRNA vaccines currently deployed against COVID-19 utilize lipid-based nanoparticles as delivery vehicles. The mRNA cargo is placed inside a shell composed of synthetic lipids and cholesterol, along with PEG to stabilize the mRNA molecule against degradation. The vaccine produced by Pfizer/BioNTech creates nanoparticles from 2-[(polyethylene glycol)-2000]-N,N-ditetradecylacetamide, or ALC-0159, commonly abbreviated simply as PEG (World Health Organization, 2021, January 14). The Moderna vaccine contains another PEG variant, SM-102, 1,2-dimyristoyl-rac-glycero-3-methoxypolyethylene glycol2000 (World Health Organization, International Journal of Vaccine Theory, Practice, and Research2(1), May 10, 2021 Page | 482021, January 19). For convenience we will abbreviate both PEG-modified lipids as PEG, and refer to the vaccines as PEGylated according to standard nomenclature. The lipid shell plays a triple role. First, it protects the genetic material from degradation prior to cellular uptake. Second, the lipid shell, which also contains cholesterol, facilitates cellular uptake through fusion with the lipid membrane of the cell and subsequent endocytosis of the lipid particle, invoking naturally existing processes. And finally, it acts as an adjuvant (Ho et al., 2021). It is in this latter role asimmune stimulant that most concerns have been raised regarding the widespread use of PEG in an injection therapy. In an article published in May 2019, prior to large clinical trials involving these PEGylated vaccines, Mohamed et. al. (2019) described a number of concerning findings regarding PEG and the immunological activation it had been shown to produce, which includes humoral, cell-mediated, and complement-based activation. They note that, paradoxically, large injection doses of PEG cause no apparent allergic reaction. Small doses, though, can lead to dramatic pathological immune activation. Vaccines employing PEGylation utilize micromolar amounts of these lipids, constituting this potentially immunogenic low-dose exposure. In animal studies it has been shown that complement activation is responsible for both anaphylaxis and cardiovascular collapse, and injected PEG activates multiple complement pathways in humans as well. The authors of one study conclude by noting that “This cascade of secondary mediators substantially amplifies effector immune responses and may induce anaphylaxis in sensitive individuals. Indeed, recent studies in pigs have demonstrated that systemic complement activation (e.g., induced following intravenous injection of PEGylated liposomes) can underlie cardiac anaphylaxis where C5a played a causal role.” (Hamad et al., 2008) It is also important to note that anaphylactoid shock in pigs occurred not with first injected exposure, but following second injected exposure (Kozma et al., 2019). The presence of antibodies against PEG is widespread in the population (Zhou et al., 2020). Yang and Lai (2015) found that around 42% of blood samples surveyed contained anti-PEG antibodies, and they warn that these could have important consequencesfor any PEG-based therapeutics introduced. Hong et. al. (2020) found anti-PEG antibodies with a prevalence up to 72% in populations with no prior exposure to PEG-based medical therapy. Lila et. al. (2018) note that the “existence of such anti-PEG antibodies has been intimately correlated with an impairment of therapeutic efficacy in tandem with the development of severe adverse effects in several clinical settings employing PEGylated-based therapeutics.” Anaphylaxis to vaccines has previously been assumedto be rare based on the frequency of such events reported to VAERS, a database established by the Centers for Disease Control and Prevention in 1990 for reporting of adverse events related to vaccines (Centers for Disease Control and Prevention, 1990; Su et al., 2019). While rare, anaphylaxis can be life-threatening, so it is important to monitor for the possibility in the short period following vaccination (McNeil et al., 2016).Sellaturay et. al., after reviewing 5 cases of anaphylaxis they link to PEG exposure, one near-fatal and involving cardiac arrest, write, “PEG is a high-risk ’hidden’ allergen, usually unsuspected and can cause frequent allergic reactions due to inadvertent re-exposure. Allergy investigation carries the risk International Journal of Vaccine Theory, Practice, and Research2(1), May 10, 2021 Page | 49of anaphylaxis and should be undertaken only in specialist drug allergy centres.” (Sellaturay et al., 2020). In fact it has already been demonstrated that pre-existing antibodies to PEG are linked to more common and more severe reactions upon re-exposure (Ganson et al., 2016). Is anaphylaxis upon exposure to PEG happening with a frequency relevant to public health? Numerous studies have now documented the phenomenon (Lee et al., 2015; Povsic et al., 2016; Wylon et al., 2016). Anaphylactic reactions to the mRNA vaccines are widely reported in the media (Kelso, 2021) and, as noted above, have been frequently reported in the VAERS database (690 reports of anaphylaxis following SARS-CoV-2 vaccines up to January 29, 2021). There are also some initial case studies published in the peer-reviewed literature (Garvey & Nasser, 2020; CDC COVID-19 Response Team, 2021, January 15). Anaphylaxis reactions to vaccines prior to these COVID-19 vaccines were generally reported at rates less than 2 cases per million vaccinations (McNeil et al., 2016), while the current rate with the COVID-19 vaccinations was reported by the CDC to be more than 11 cases per million (CDC COVID-19 Response Team, 2021, January 29). However, a published prospective study on 64,900 medical employees, where their reactions to their first mRNA vaccination were carefully monitored, found that 2.1% of the subjects reported acute allergic reactions. A more extreme reaction involving anaphylaxis occurred at a rate of 247 per million vaccinations (Blumenthal et al., 2021). This ismore than 21 times as many as were initially reported by the CDC. The second injection exposure is likely to cause even larger numbers of anaphylactic reactions
there is much more of course, but it is hard to send everything here
(Please look below at the 2016 paper regarding Hospira and Baxter - in my opinion we DID NOT HAVE a control group. Saline solution contains nanotech).
The FUTURE according to THEM:
https://www.mdpi.com/2571-5577/4/2/27/htm "Although this concept can also additionally
mean totalitarian rule to many, ultimately, leveraging the IoVT era can be the maximum
applicable manner to keep away from pandemics globally."
"flu vaccines"
https://www.fiercepharma.com/vaccines/deaths-rattle-south-korea-s-seasonal-flu-vaccination-but-authority-presses-ahead-free
https://www.nih.gov/news-events/nih-research-matters/nanoparticle-based-flu-vaccine
https://www.azonano.com/article.aspx?ArticleID=3070
Nasal delivery - nanoemulsions of vaccines can be safely inhaled in a nasal spray. This
is a convenient method of delivery, which does not suffer from the dosing problems of
oral delivery. Nanoemulsions are also stable at room temperature for relatively long
periods of time, which would allow them to be distributed to remote locations and
developing countries more easily. They have been shown to be effective in
administering hepatitis B vaccinations in animal trials, although more study is needed
to determine the effects on patients with allergies or respiratory problems
https://europepmc.org/article/med/26814441
Functionalized graphene oxide serves as a novel vaccine nano-adjuvant for robust stimulation of cellular immunity.
(Polyethylene glycol (PEG) and various types of polyethylenimine (PEI) were used as
coating polymers)
https://www.researchgate.net/publication/309756855_Microparticles_and_Nanoparticles_Delivered_in_Intravenous_Saline_and_in_an_Intravenous_Solution_of_a_Therapeutic_Antibody_Product (this protein aggregation is actually a huge problem = amyloid plaque formations)
HOSPIRA is the saline solution used by Pfizer:
IV saline in bags manufactured by both Hospira and Baxter contained 1600-8000 microparticles/mL and 4-73 × 10⁶ nanoparticles/mL in solution. When IV immunoglobulin was diluted into the IV saline, 3700-23,000 microparticles/mL and 18-240 × 10⁶ nanoparticles/mL were detected. During processing of the solution through the IV system, in-line filters removed most microparticles. However, there were still 1-21 × 10⁶ nanoparticles/mL in IV saline and 7-83 × 10⁶ nanoparticles/mL in IV immunoglobulin diluted in saline.
This is worthy of looking at:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5468375/
"Intravenously injected nanomaterials can adsorb a wide range of proteins in the blood (39). The bio-corona of blood proteins is rapidly formed, and it has been shown to affect hemolysis and thrombocyte activation "
and
biomedcentral.com - https://particleandfibretoxicology.biomedcentral.com/articles/10.1186/s12989-016-0168-y
https://www.frontiersin.org/articles/10.3389/fphar.2020.01206/full
I think you have seen this one:
https://www.ncbi.nlm.nih.gov/labs/pmc/articles/PMC5039077/
Additionally:
Veklury© or remdesivir is an altrononitrile.
Remdesivir is a nitrile. More specifically, an altrononitrile. It is described by its IUPAC name: lalanine, N-((S)-hydroxyphenoxyphosphinyl)-, 2-ethylbutyl ester, 6-ester of 2-C-(4- aminopyrrolo(2,1-f)(1,2,4)triazin-7-yl)-2,5-anhydro-d-altronitrile.
Nitriles are very well known to chemists. They are very reactive molecules and very often toxic. They are used in the chemical industry to produce insecticides, pesticides, strong detergents to materials that are difficult to remove, such as metals.
Nitriles are cyanide compounds. This class of compounds is characterized by the presence of C≡N (cyan) and includes cyanides and nitriles (R-C≡N), as well as related compounds. chemical compounds such as cyanogens, isocyanates and cyanamides. They owe their
owe their toxicity primarily to the cyanide ion, which, when released into the body, is capable of inhibiting many enzymes, especially cytochrome oxidase. Death, which occurs more or less quickly depending on the rate of cyanide ion release, is the result of chemical asphyxiation at the cellular level. (http://web.archive.org/web/20200907075757/http://www.francesoir.fr/societe-sante/l-entreprise-gilead-aurait-elle-dissimule-la%20vraie-toxicite-du-veklury-remdesivir)
So, also Remdesivir by itself may very well lead to poisoning/oxidative stress/death by suffocation
https://onlinelibrary.wiley.com/doi/10.1002/anie.201806906
https://www.sciencedirect.com/science/article/abs/pii/S0003986117307725?via%3Dihub
https://www.sciencedaily.com/releases/2018/08/180823113613.htm
https://www.frontiersin.org/articles/10.3389/fphys.2020.00433/full
So my humble opinion is that the virus is just another burden, another oxidative stress. But, in most cases. it is not the cause of so called Covid" symptoms, injuries and deaths; toxicity/poisoning is.
HQC, Ivermectin, Vitamin D3, other antioxidants - anything what would prevent oxidative stress/poisoning - is a perfect treatment of C-19 but also to keep the vaccinated people alive, prevent their injuries, for as long as they need to detoxify.
After careful study of all those issues, my assessment is: This is not the virus that kills or injures, but whatever the people are poisoned with. It may also be 5 G radiation, as science proves that it also causes oxidative stress. And a flu is additional oxidative stress.
google - masks -graphene - images
Biomass Graphene 3 Ply Non-woven Graphene Face Mask China Manufacturer (archive.org)
(http://web.archive.org/web/20200804115842/https://bsg-i.nbxc.com/product/77/9c/aa/
9362cb7afe5f374fc952f25859.jpg)
Reputation well non-woven Biomass Graphene disposable 3 ply Face Mask earloop for
kids
https://recalls-rappels.canada.ca/en/alert-recall/graphene-face-masks
http://web.archive.org/web/20210404000450/https://www.kamloopsthisweek.com/health-canada-recalls-masks-containing-graphene-as-it-assesses-risks-to-people-1.24302799
https://cn.tradekey.com/product_view/Disposable-Graphene-Face-Mask-3ply-Earloop-Mask-Wholesale-9403187.html
http://hdreporter.com/health/9646-are-graphene-coated-face-masks-a-covid-19-miracle-or-another-health-risk
https://www.hsmsearch.com/Graphene-enhanced-face-masks
https://pubs.rsc.org/en/content/articlelanding/2016/py/c6py00639f/unauth
Filomicelles and nanoworms are an emerging subclass of nanomaterials with a special
elongated shape. The physical properties of a filomicelle are distinct from a traditional
spherical micelle, and as such have attracted tremendous interest in a variety of research
areas. In this review, we highlight the substantial progress in the synthesis and application of
polymeric nanoworms over the past two decades. Synthetic techniques summarized in this
review are particle replication in nonwetting templates (PRINT), film stretching, self-assembly
(SA), crystallization-driven self-assembly (CDSA), polymerization-induced self-assembly
(PISA), and temperature-induced morphological transformation (TIMT). The applications of
filomicelles as (i) templates for inorganic nanoparticles, (ii) building blocks for superstructures,
(iii) synthetic dendritic cells for immunotherapy, (iv) constituents of thermoresponsive gels for
biomedical applications, and (v) nanocarriers for cancer drug delivery are subsequently
discussed. In the conclusion, we describe the current trajectory of research in the field and
identify areas where further developments are of urgent need.
"You will own nothing, but you will be happy (or at least you will think so)"
https://www.sciencedirect.com/science/article/abs/pii/S0021979719313797
Dopamine-assisted one-pot synthesis of gold nanoworms and their application as photothermal agents
http://web.archive.org/web/20200919081413/https://www.weforum.org/agenda/2016/11/shopping-i-can-t-really-remember-what-that-is?utm_content=buffer60978&utm_medium=social&utm_source=twitter.com&utm_campaign=buffer
https://pubs.acs.org/doi/10.1021/acsnano.1c05075
https://www.chemistryworld.com/news/graphene-slips-deeper-into-lungs-than-predicted/3001864.article
Researchers discover that once graphene enters the lungs the immune system has
trouble getting rid of it.
Graphene nanoplatelets can penetrate deeper into the lungs than their size would
suggest, say UK researchers. And once there, the body’s natural defences cannot deal
with them effectively. Chronic exposure could therefore lead to inflammation and
disease in a similar way to asbestos fibres.
Etc.
Shedding:
GRAPHENE SHEDDING AND RUFFLING:
Graphene Oxide Nanosheets Stimulate Ruffling and Shedding of Mammalian Cell Plasma
Membranes https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5120764/ Published in final edited form as: Chem. 2016 Aug 11; 1(2): 273–286.
doi: 10.1016/j.chempr.2016.06.019
Pfizer documents - Clinical protocol (Pages 67-69):
https://cdn.pfizer.com/pfizercom/2020-11/C4591001_Clinical_Protocol_Nov2020.pdf
PCR:
https://www.sciencedirect.com/science/article/pii/S2666386420301879
Nose-to-Brain Translocation and Cerebral Biodegradation of Thin Graphene Oxide Nanosheets
Highlights
Thin graphene oxide sheets can translocate from the nasal cavity to the brain
Translocation is size dependent, with ultrasmall nanometric sheets translocating the most
Kinetics of graphene oxide accumulation are time dependent and brain-region-specific
Brain-accumulated graphene oxide undergoes changes consistent with biodegradation
The nasal route represents a means by which nanomaterials can gain access to the brain in exposed individuals.14 Per the International Commission on Radiological Protection (ICRP) model of fractional depositions of inhaled particles,15 the aerodynamic diameter of an inhaled particle can influence its deposition in the pulmonary tract. Nanometer-sized particles are expected to deposit predominantly in the nasopharyngeal and laryngeal regions. Considering the anatomy of the olfactory region in the nose, which connects directly and indirectly with the brain,16 nanoparticle deposition in this region may result in nose-to-brain translocation. In support of this, epidemiologic studies, clinical trials, and animal experiments exploring the biodistribution of inhaled nanoparticles have identified the materials in extrapulmonary organs, including the brain.
Several modes of transport by which nanoparticles may enter the brain from the nasal cavities have been considered, including transport via axons of olfactory (olfactory neural pathway)31 and trigeminal (trigeminal pathway)32,33 neurons or via spaces between neuronal axons (paracellular transport).34 Other pathways include paracellular or transcellular transport in relation to olfactory sustentacular epithelial cells.16,35,36 Nanoparticles may also undergo absorption into the systemic circulation and then permeate the blood-brain barrier (BBB) to access the brain.16 The latter pathway remains unlikely due to various defenses of a healthy BBB, including efflux pumps and narrow tight junctions.37,38
https://www.frontiersin.org/articles/10.3389/fnsys.2018.00012/full - Interfacing Graphene-Based Materials With Neural Cells
How to Reach the Brain: G-Based Nanocarriers and the Blood-Brain Barrier
Common mechanisms of cytotoxicity of G nanosheets have been reported in literature on
different cell types, and include the physical interaction with cell membranes (Seabra et
al., 2014); disruption of cell cytoskeleton (Tian et al., 2017); oxidative stress due to
production of reactive oxygen species (ROS; Chen M. et al., 2016; Mittal et al., 2016);
mitochondrial damage (Pelin et al., 2017); DNA damage, such as chromosomal
fragmentation, DNA strand breakages, point mutations and oxidative DNA alterations
(Akhavan et al., 2012; Fahmi et al., 2017); autophagy (Chen et al., 2014); and apoptosis
and/or necrosis ... . It is clear, however, that G nanosheets may cause adverse environmental and health effects, leaving open the debate about their use as biomedical platform
https://www.nsmedicaldevices.com/news/graphene-sensor-covid-19-test/
https://www.medgadget.com/2021/06/graphene-sensor-for-rapid-covid-19-detection.html
https://www.nasdaq.com/press-release/sona-nanotech-withdraws-rapid-covid-19-antigen-test-application-based-on-feedback
Sona Nanotech is a nanotechnology life sciences firm that has developed multiple proprietary methods for the manufacture of various types of gold nanoparticles.
https://phys.org/news/2020-08-graphene-oxide-based-rapid-infections.html
https://www.biospace.com/article/new-graphene-chemo-phononic-test-for-sars-cov-2-may-challenge-pcr-assays/
https://www.grapheneuses.org/graphene-sensor/
https://www.azonano.com/news.aspx?newsID=37676
WAKE UP -it's being done !!! :
https://www.ledgerinsights.com/national-cybersecurity-center-partners-with-id2020-alliance/
https://www.ledgerinsights.com/trust-over-ip-digital-identity-consortium-ibm-r3-mastercard/
https://blockchainmagazine.net/us-firm-integrates-nanotechnology-blockchain-for-covid-19-immunity-passports/
https://dailycoin.com/nano-nano-could-lead-mastercards-crypto-development/
https://pubs.acs.org/doi/10.1021/acsnano.1c05075
Nanoparticles are widely used in electronics, aeronautics, energy, agriculture, cosmetics,
medicine, textile production, and many other fields. They are currently used to administer
drugs, proteins, genes, vaccines, polypeptides, and nucleic acids
In short, I would say this:
We are definitely playing Russian roulette with these toxic injections. From my observations, it seems that for many, if they don't die or get injured quite immediately, it takes from 5 months to about a year. Definitely one of the mechanisms of this nano-technology and peptides (proteins), in addition to inducing acute oxidative stress with all its effects, such as blood clotting, organ failure, strokes, heart failure, etc., is AMYLOID PLAQUE FORMATIONS in the presence of quantum dots. These self-assembling structures grow under the influence of certain factors, including temperature, UV light, ultrasound, PH, etc.
Thus, prevention and treatment tactics should be based on counteracting oxidative stress and disassembling these self-assembling peptide nano-semiconductors. My research shows that NAC (N-acetylcysteine) does this and all other antioxidants, including a diet rich in antioxidants would help achieve the goal. NAC doses should be high, at least initially.
These antioxidants and detox should be continued for as long as needed. Since these toxic components are deposited in the bone marrow, ovaries, spleen, etc. it can take a long time for one to eventually biodegrade these. So, people should have good amounts of life-saving antioxidants and research into this.
Sorry, but this is slaughter. We need to stop it.
This is "CORONA" and the reason why those "vaccines" are so coerced, forced, advertised - it has nothing to do with health, but everything to do with their greed and power trip:
https://www.ohsrep.org.au/nanotechnology_-_a_new_hazard - GRAPHENE AND GRAPHENE OXIDE: A “NEW ASBESTOS”
https://www.ledgerinsights.com/blockchain-ai-iot-convergence-european-commission/ - European Commission explores blockchain, AI, IoT convergence
https://dailycoin.com/nano-nano-could-lead-mastercards-crypto-development/ - Nano: Tiny, Yet So Powerful
Nano (NANO) formerly known as RaiBlockd is a decentralized and open-source cryptocurrency based on the direct acyclic graph (DAG) architecture. Using a block-lattice data structure, it operates without third parties.
https://blockchainmagazine.net/us-firm-integrates-nanotechnology-blockchain-for-covid-19-immunity-passports/ - U.S.-based quantum dot producer QMC (Quantum Materials Corp) declared its blockchain-based QDX HealthID for transparency in disease testing and immunization for infectious diseases. The aim is to assure the authenticity of health data and aid individuals to re-join the workforce soon.
Quantum dots are nanoparticles made up of semiconductor materials that transmit various colors when illuminated by light. This color depends on their dimension and the way they were produced. QMC has built a track and trace solution utilizing quantum dots and blockchain to confirm the creation of products and counterfeiting.
The authentication solution is blended with QDX HealthID for monitoring and tracking the mutinies of diseases, like the COVID-19. The solution validates individuals being tested, the persons conducting the test, and the test kits.
In more simplistic terms, QDX HealthID warrants that testing data is safe and not tampered with. Recently, health reports and medical certificates are being issued on paper, which makes them simple to forge.
“Not only does this service facilitate improved health outcomes for patients, but it also underpins back-to-work certifications, sometimes referred to as immunization passports,” said Stephen B. Squires, President & CEO of QMC in a statement.
With the health data supported by blockchain, governments and health agencies can form new plans and security measures to hold the spread of COVID-19 and other diseases. Additionally, individual users can evaluate their immunization passport, utilizing a mobile application. The app highlights color-coded indicators — yellow, green, and red. If the app displays the green indicator, the individual has the authorization to interact in social and work environments. This indicator can be bestowed and authenticated by others utilizing a QR code.
“The world must have a system that eliminates the fears and anxiety of not knowing who is able to return to work,” said Les Paull, CEO of QMVT, the unit responsible for sales and marketing of QMC’s innovations in a statement. The solution is hosted on the Microsoft Azure cloud and can combine with existing EMR systems. It is based on the Hyperledger Sawtooth enterprise blockchain, and for smart contracts, it’s applying the DAML (Digital Asset Modeling Language).
CORONA VIRUS ... https://link.springer.com/chapter/10.1007/978-3-030-58861-8_2 https://ieeexplore.ieee.org/document/9298084 DCCORONA
https://projects.ics.forth.gr/_publications/CORONA2015.pdf CORONA
https://www.nature.com/articles/s41467-019-12470-5 - Tailoring the component of protein corona via simple chemistry
Nanomaterials have been extensively explored for biomedical applications, such as drug
delivery and early-stage disease diagnosis1,2,3,4,5. The relatively slow translation of
nanomedicine into clinical applications has encouraged researchers to pursue the yet
unknown factor behind the failure of many nanomedicines6,7,8,9. One major limitation of
engineered nanomaterials is their undetermined fate in vivo, which is revealed to be
associated tightly with the protein corona effect6,8. Principally, shortly after entry into the
blood, the outer surface of nanomaterials become passivated by numerous biological species,
the dominant type of which is serum protein. This is where the term protein corona effect got
the name10. The protein corona substantially remodels the nanomaterials’ manner of
interaction with cells11,12,13,14. Therefore, an in-depth understanding of the protein corona
effect can effectively facilitate the translation of nanomedicines. To date, most efforts have
been devoted to understanding the composition of protein coronas as well as their biological
implications15. For instance, Dawson and co-workers16 nicely uncovered mechanism
underlying the protein corona-targeting ligand interaction. Tenzer et al.17 showed that the
protein corona can be established within minutes of exposure to body fluid-mimicking
medium, which led to drastic pharmacokinetic changes that also determine the
cytotoxicity of the nanoparticles.
In an effort to mitigate the complications caused by the protein corona effect, initial
attempts wherein anti-fouling coating was utilized were made. The best known polymer
developed to this end is poly(ethylene glycol) (PEG)18,19,20. I
Wow, thank you for putting all this together. I had never heard of Internet of nano things. And I knew peg was toxic but I didn't know it's relationship to nanoparticles. Damn, this technology is so advanced, people have no idea. It will take me awhile to go through everything, but some of this are things I hadn't heard before.
I had lunch with a friend that I hadn't seen in over a year, triple injected. It turns out she's having worsening heart problems, she was totally healthy and active. Luckily she's open to it being myo or pericarditis, and we are in touch about detoxing.
https://link.springer.com/chapter/10.1007/978-3-030-58861-8_2
https://ieeexplore.ieee.org/document/9298084 DCCORONA
https://projects.ics.forth.gr/_publications/CORONA2015.pdf CORONA
https://www.instructables.com/Intelligent-Street-Light-Using-LoRa/ This prototype works on Master-slave configuration, where each street light acts as slave, and LoRa Gateway acts as the master. As Lora gateway has longer range compared to other communication services like wifi, Bluetooth, NFC etc.. Though GSM has the longer range it includes subscription charges which are not there is LoRa (Free of charge)and also LoRa consumes very less amount of power during operation. Master is connected to the internet so that user can remotely monitor street lights.So Large number of street lights can be connected and controlled from the Master gateway.
https://www.manufacturer.lighting/info/83/ - Street Lighting Meets the Internet of Things (IoT)
The Internet of Things (IoT) is a network of uniquely identifiable physical objects (things) which are internetworked to achieve control and information exchange via an information carrier based on standard communication protocols. IoT allows a wide variety of devices to create seamless communication and contextual interactions remotely across the existing network infrastructure. IoT enables all physical objects to act as uniquely addressable nodes and adds network functions to enhance and extend their main functionality. This feature introduces tremendous new capabilities and create a number of opportunities by providing controllable and even personalized interoperability and manageability in today's Smart City and Smart Energy Management Systems.
Adding IoT connectivity to street lights quantifies the benefits of sustainability development. The combination of network communicating, intelligent sensing, and sophisticated data analysis capabilities allow municipal authorities to monitor and dynamically control the street lighting systems. The IoT based lighting technology resolves the scalability challenges to manage a large number of streetlight facilities by aggregating and act on large amounts of data generated by IoT street lights to improve urban lighting services, maximize energy savings and reduce operation costs. As such, IoT networking technology creates a practical opportunity for more direct integration of LED street lighting into computer-based systems
The Internet of Things goes beyond powerful machine-to-machine (M2M) communications in street lighting management. A large number of applications can be put into practice within a broader context of the extensive development of smart city initiatives across the world. Smart street lighting systems can be implemented as a critical component in the smart city infrastructures and provide extended capabilities such as public safety monitoring, traffic management, weather monitoring, environmental protection, smart parking, WiFi accessing, Utility metering and leakage sensing, and voice broadcasting, etc. - or this" Mark Steele lives in the northern England town of Gateshead, which is a test site for these LED street lamps. He also claims to be a member of IEEE (the Institute of Electrical and Electronics Engineers) and is knowledgeable in what might be causing these strange maladies in Gateway. In his humble yet experienced opinion, the fine citizens of Gateway are being bombarded by 5G radiation emitted from the street lamps and the towers that control the wireless communications used to manipulate them. After noticing that his neighbors were reporting an unusual number of nosebleeds, cancer cases and worse, Steele believes it’s they that are being manipulated by the local government and businesses.“We are seeing babies dying in the womb as these transmitters are situated outside people’s bedroom windows. It’s a humanitarian crisis.” - Lighting experts say 5G is the future of street illumination. By equipping light poles with sensors and communications gear, cities can measure traffic, parking, noise, crowds, pollution, weather and other conditions and regulate the intensity of lighting on a schedule or on-the-fly. City officials love the idea because wireless communications eliminate the need for expensive digging, construction and repairs.If it weren’t for those pesky nosebleeds and birth defects.“Gateshead Council is NOT carrying out secret government trials in 5G technology via our street lights. We don’t know how these conspiracy stories start, but we are happy to report that this is exactly what these are. These tales are completely untrue and you should ignore them. Please be assured that there is no scientific basis or credible evidence for any of these scare stories about street lights causing cancer and other illnesses. We’ve taken advice from Public Health England who reviewed guidance issued by the World Health Organisation, the International Commission on Non-Ionizing Radiation and others, and they have confirmed that there is no risk.” The Gateshead Council denies it's using 5G and has been dealing with Steele and other protesters who originally started complaining that birds and flying insects began disappearing from their trees and yards soon after the towers and lights were installed. The protesters refer to people like Professor Ulrich Warnke, from the University of Saarland, who said in an interview with the Daily Mail that the EMF radiation from LED streetlights “causes disruption to the body’s nitrogen monoxide system, which keeps cells healthy and controls gene expression.” And they refer to the European Academy for Environmental Medicine, which says EMF radiation is linked to cancer and insomnia. etc. (https://mysteriousuniverse.org/2018/05/5g-streetlights-may-be-causing-mysterious-ailments/) Anyway, those lights are not normal, that's for sure and so many turned just purple UV light and surely this is harmful, but hidden behind the led light
https://www.greenbaypressgazette.com/story/news/local/2022/02/08/why-some-streelights-appear-purple-northeastern-and-central-wisconsin/9225015002/ , https://www.wfla.com/news/local-news/why-are-some-street-lights-in-tampa-tinted-purple-teco-explains/ , https://www.cbsnews.com/minnesota/news/purple-street-lights-apple-valley/ , http://www.abilene-rc.com/news/some-abilene-streetlights-have-turned-purple-here-is-evergy-s-explanation-for-the-color-change/article_d5f55584-58ff-11ec-ab8d-bb745a683c80.html ) This is their industrial revolution - but whqat they are not telling people is that they started to use UV lights - for exampleAMA states: "In the case of white LED light, it is estimated to be five times more effective at suppressing melatonin at night than the high pressure sodium lamps (given the same light output) which have been the mainstay of street lighting for decades. Melatonin suppression is a marker of circadian disruption, which includes disrupted sleep." (American Medical Association warns of health and safety problems from ‘white’ LED streetlights) - https://www.fda.gov/medical-devices/coronavirus-covid-19-and-medical-devices/uv-lights-and-lamps-ultraviolet-c-radiation-disinfection-and-coronavirus - UVA: UVA radiation is less hazardous than UVB radiation but is also significantly (approximately 1000 times) less effective than either UVB or UVC radiation at inactivating other SARS viruses. UVA is also implicated in skin aging and risk of skin cancer.
and there is way more than thins, ugh...
2-3000 mg NAC and plenty of other antioxidants -
daily 2000-3000 mg NAC, daily dose of Zinc 50 mg, Vitamin C 2000-3000, Quercetin 1500mg. You can add other antioxidants such as Resveratrol, Vitamin D3, Vitamin E, Q-10, etc
there are clays and baths and grounding and juicing but I've been using just supplements, they work - I sent it to someone else, I might have sent it, in case I paste it again, as this is a quintessence:
This would be a short summary : We are definitely playing a Russian roulette with those toxic injections. My observation is that for many, if they don't die or get injured quite immediately, it takes between 5 months to about one year. Definitely one of the mechanisms of this nano technology and peptides (proteins) in addition to just causing acute oxidative stress with all its outcomes, such as blood clotting, organ failure, strokes, heart failure, etc., is AMYLOID PLAQUE FORMATIONS in presence of quantum dots. Those self-assembling structures grow under the influence of certain factors including temperature, UV light, ultrasound, PH, etc.
So, the tactic of prevention and treatment should be to address oxidative stress and to disassemble those self-assembling peptide nano semiconductors. From my research it is clear NAC (N-acetylcysteine) does it and all other antioxidants, including antioxidant rich diet would help to reach the goal. NAC doses should be high, at least in the beginning.
Those antioxidants and detox should be continued for as long as it is needed. Since those toxic ingredients deposit in bone marrow, ovaries, spleen, etc., it may take a long time for one to eventually biodegrade those. So, people should have good amounts of life saving antioxidants and research in this direction.
I am sorry, this is a slaughter. We MUST STOP IT.
Here are very good hearings organized by Australian senators, with abundance of arguments and facts regarding this crime by most of the "leaders", WHO and other perpetrators: https://www.malcolmrobertsqld.com.au/the-covid-inquiry-2-0/#htoc-julian-gillespie1