Very interesting theory! I recently attended an event with several of the "freedom doctors" during which one of them mentioned something about smokers possibly being less vulnerable to infection (although still vulnerable and still at risk for serious complications) because the nicotinic receptors are already occupied.... Pardon, I'm not a biologist and likely fumbling the terminology, but I believe it was that these receptors were, like ACE2, amenable to the virus receptor binding domain, so having niccotine in the bloodstream could be protective - at least for those sites.
Among therapeutic options6–8, the use of the anti-parasitic drug ivermectin (IVM), has been proposed, given its possible anti-SARS-CoV-2 activity9. Ivermectin is a positive allosteric modulator of the α-7 nicotinic acetylcholine receptor 10, which has been suggested to represent a target for the control of Covid-19 infection11, with a potential immunomodulatory activity12.
Anti-COVID-19 efficacy of ivermectin in the golden hamster
and spotted the problem and the solution right away, a mere 2 weeks *AFTER* agro-business magazines were advising here *against* taking Ivermectin for COVID.
Quote:
"The neurotoxin motifs. Amino acid sequence alignment of the motifs found in toxins from snakes of the Ophiophagus (cobra) and Bungarus genera, in G from three RABV strains and in S from SARS-CoV-2."
There’s a chart somewhere from the beginning of 2020-ish showing flu-like deaths from 2017-18 being an ordinary out-of-the-ordinary spike in the chart of flu deaths. Ordinary because such a spike happens every so many flu seasons, and it was roughly on schedule. Out-of-the-ordinary because it was taller than the others. I can’t seem to find it now. And back then I didn’t know all this type of stuff needed to be screen grabbed.
Anyway, I’ve been thinking along the lines of this article for some time due to that flu chart, and because of my own experiences through the last five years. I got “pneumonia” in 2017, and so did many around me in the small town I lived in at the time (pacific northwest). The people I know that got that sickness or similar to it at that time didn’t get COVID at all over the last 2 years. Despite several exposures. Our own conversations have included speculation of cross-immunity with respect to the underlying cause of that 2017 sickness. Consider also, that in the US, the Pacific Northwest has shown more resilience to COVID, when looking at the data. Even though the data are corrupt, it is roughly apples to apples in this way. I wonder where else that mystery pneumonia blew up and how the COVID numbers look there now?
Back in 2017, I was convinced that we had a “cousin” of MERS, because the experience closely matched what I read about it, and we were exposed to vectors for MERS, even though it was considered no big deal by then. My current hypothesis is that they’ve been trying to “burn the house down” since at least 2003-4 with SARS-CoV, 2008-9 with H1N1, 2013-4 MERS and avian flu, 2017-8 no-name, 2019+ SARS-CoV-[x]. But something always put the fire out (because they’re not actually in control like they like to think they are). The conspirators in this hypothesis didn’t realize that a perception that the house was burning down was more effective and easier to pull off. Thus, COVID-19 was born.
Extending the conspiracy theory further, one might conclude that the jabs were a fire they could guarantee because it’s going straight into the blood - OR - that it was a money grab, seizing the opportunity presented by everyone running out of the house panicked, but will nevertheless burn the house down as an unintended intended consequence. Like an arsonist that keeps failing, then decides to dupe the homeowners into letting him inside to “fix” a problem that doesn’t exist. He either intends to set the house ablaze from within, or maybe he changed his intention to merely stealing everything valuable but then clumsily bumps a candle into a curtain and burns the house down anyway, having unintentionally succeeded in his original endeavor. Or maybe a little of both. I’m not sure yet, because Moderna folks seem to act like the first type, while Pfizer folks seem to act like the second. Every once in a while, I get the distinct feeling that animal doctor Bourla isn’t happy with his role in this. His guilt and humanity occasionally leak.
This theory would also explain why ~80% of the population seems to be immune. Case in point, the USS Roosevelt, where even in the tight quarters, only 20% of the crew contracted the virus. There have been many other instances showing that only about 20% of the population is actually susceptible, or capable of "catching COVID".
That adds another dimension of authenticity to your theory.
I've considered myself "Ground Zero" for herd immunity. I've played with Corona viruses in many species due to my work for the last 30 years. I've gone to help friends who have been ill, or quarantined due to "SARS-CoV2", because I've had no fear. Yet, even in close quarters with many that are ill, and/or test positive, I have yet to have so much as a sniffle. If it was as bad as the media and Fraudci portrayed, I should have been ill and dead 2+ years ago. I guess all of my previous Corona virus exposures conferred cross protection. (Maybe it wasn't so novel after all?) But if they tell us "they missed the strain of the flu virus circulating this year, but you should run out and get vaccinated anyway, because you get cross protection", how can they not realize that even having antibodies to the common cold, (also a Corona virus) is cross protective?
I think they KNOW there is cross protection, but that doesn't feed the fear. Not only that, but over 70% of the surface proteins are the same as other Corona viruses. (Again, maybe it isn't so novel).
Heard about the quasispecies swarm from Dan Sorotkin at Harvard2TheBigHouse substack a while back. His theory was that the virus was originally a Live Attenuated Virus Vaccine that was released at the Chinese Military Games or possibly earlier and is mutating back to a more virulent/original form prior to the attenuation procedure. This would fit in nicely with your musings here, Matthew.
Nice sleuthing (that is the right work for investigative work?)!
To add on: where are the vaping equipment manufactured? I'd guess that PRC gets you your money back minus commission. Are they put together in a sterile workc environment? Anyone thinks that about chinese manufacturing, I've got a bridge to sell you in Tamanrasset.
What I'm saying is, could it be so simple that the soon-to-be-the-Covid we know virus was initially spread by contaminated shipments of vaping gear?
After all, people needing oral stimulation suck those things. What if workers putting them together had colds? I don't think you get sick days with pay in chinese factories, meaning you work until you can't (ain't capitalism grand?).
So a lot of the people sucking the fashionable pacifiers might of simply licked themselves a little prior infection, and that way developing as you say better prtection but higher susceptibility (kind like how a person who's had the clap multiple times is more susceptible to infection, should the condom break).
I'm just speculating since the majority of cheap products are made there, and China not being known for any kind of labour or environmental regulations.
(Re-reading my initial post I see why I shouldn't write before coffee - egads, grammar and spelling worthy of the US president.)
And as an aside concerning how a contaminant may be released:
I know two people working garbage collection/sorting in Sweden. One at the conveyor belt (yes, we use manual labour for that, lowest legal wage of course and no prior training needed - it is typically done by ex-cons, migrants and disabled/cognitive deficient meaning the company gets the wage subsidised) and well, at least once a week they find canisters or containers marked "Biohazard" coming from labs or hospitals. Anything from used needles to unlabeled vials of who knows what. Those canisters are not supposed to ever go in the regular garbage.
One works managerial level. He can tell the real juicy storys. Hand grenades, a couple every year at least. As in - someone tossed a real grenade out with their regular trash. Top of his sh*t-list was a container marked "Radioactive waste". In the regular garbage. A 75 kilo container of radioactive waste ditched in a garbage dumpster somewhere. No trail.
That's here in Sweden where they shut down the line upon such incidents (the entire plant for explosives and radioactive materials). Now imagine how China handles it.
That's why I started thinking maybe some chinese person simply sneezed at enough mouthpieces during two weeks.
Great theory! And I love a great theory that comes with a side of cute furry animals.
Science is so cool, it's unfortunate that people don't know how creative it is, to come up with problem solving theories about our world that can be discussed and proven true or false or unknown. 💫
At a US county level, smoking rates were more predictive of Covid deaths than vax rates. My intuition was that smoking was simply a marker of poorer general health.
I've always wondered if the vaping illness wasn't just part of some experiment, not with the actual virus, but perhaps spike protein, or graphene dioxide, or different combinations.
I considered that hypothesis, but the basic evidence stands against it. The hospitalization curve alone conforms to expectations of viral spread and it would be magnificently fortuitous for product distribution to achieve R that just happens to compress with seasonality.
Bet against any splitting of the arrow hypothesis.
He would have done well to set his articles up with a clear story of what the quasispecies swarm means. I read his first article twice and in pieces before I knew what reading to do to build a background on the topic.
I wish I could go back and accelerate his broadcast by doing so myself, but I had my own priorities. And it's done here now.
You add an interesting twist to the theory. I know early on in France they had noticed smokers seemed to face lower covid incidence rates, so were set to conduct a study, nicotine focused I believe. Not sure if the study was conducted. (Anti-smoking groups which became aware of the proposed study immediately went into action to fight that narrative.) But that covid, before we knew of the outbreak, could be selectively targeting weakened lungs of smokers, so seeming to provide smokers with lower infection rates because they'd already naturally gained immunity from previous infection is an interesting thought. One issue though, if I remember correctly, EVALI (e-cigarette or vaping associated lung injury) was affecting predominantly the young, which goes against our early experience with known covid. There were about 2600 EVALI US cases. I don't remember, so someone correct me, were there cases in other countries? And this was for vapers; tobacco or THC. Did we also see unusual respiratory issues in analog cigarette smokers during the pre-covid period when EVALI occurred?
Not that I don't think covid seems to have been with us well before it was first announced. There's the European sewage samples showing early 2019 contamination. And the Italy stored lung tissue for the cancer study from early Semptember-ish 2019.
"Anti-smoking groups which became aware of the proposed study immediately went into action to fight that narrative."
Just like... let's generously call them "anti-vaccine-hesitancy groups"... becoming aware of the potential for successful early covid treatments belying the need for mass vaccination, and springing into action to fight the early-treatment narrative.
An unholy alliance between the FDA, anti-tobacco groups and Big Tobacco. 480,000 annual US cigarette related deaths and you can't get any of them to recommend the safer alternative, vaping.
Smoking and vaping are different. Smoking puts hot air and nicotine down into the oral cavity and lungs and maybe nasal one and heat tends to kill the virus. Also nicotine has been found to interfere with the virus attaching to the cells because it attaches to the same receptors and was shown in one study to help heal long Covid. I doubt vaping interferes with a SARS-CoV-2 viral infections the same way smoking does. I do not recommend smoking, which has other downsides.
This makes a whole lot of sense to my smooth brain.
Would be interested your thoughts on Geert's interview on most recent Highwire.
If I had an income there are many excellent substackers I would happily pay for, you being at the very top.
I have scarcely little time to watch interviews that aren't specific to a research priority. That list is long.
Very interesting theory! I recently attended an event with several of the "freedom doctors" during which one of them mentioned something about smokers possibly being less vulnerable to infection (although still vulnerable and still at risk for serious complications) because the nicotinic receptors are already occupied.... Pardon, I'm not a biologist and likely fumbling the terminology, but I believe it was that these receptors were, like ACE2, amenable to the virus receptor binding domain, so having niccotine in the bloodstream could be protective - at least for those sites.
Hum - ever heard of NAChR? Neurotoxins & NAChR? Zinc ionophores & Ivermectin?
All known since 1998 in Europe? & Since before 1492 here, where what you now call tobacco is a fundamental item of indigenous medecine.
Cheers.
1998 Krause - Ivermectin: A Positive Allosteric Effector of the a7 Neuronal Nicotinic Acetylcholine Receptor
https://sci-hub.st/10.1124/mol.53.2.283
Structure of the native muscle-type nicotinic receptor and inhibition by snake venom toxins. Neuron 106, 952–962.
Unwin, N. (2000). The Croonian Lecture
https://archive.is/KGrVf
https://www.sciencedirect.com/science/article/pii/S0896627320302191
2004 Bioactivity of a peptide derived from acetylcholinesterase: involvement of an ivermectin-sensitive site on the alpha 7 nicotinic receptor.
https://sci-hub.st/10.1016/j.nbd.2004.02.009
A poor paper, but still:
Among therapeutic options6–8, the use of the anti-parasitic drug ivermectin (IVM), has been proposed, given its possible anti-SARS-CoV-2 activity9. Ivermectin is a positive allosteric modulator of the α-7 nicotinic acetylcholine receptor 10, which has been suggested to represent a target for the control of Covid-19 infection11, with a potential immunomodulatory activity12.
Anti-COVID-19 efficacy of ivermectin in the golden hamster
https://www.biorxiv.org/content/10.1101/2020.11.21.392639v1
The nicotine paper I linked to was NAChR
Yes, Konstantinos Poulas was among the earliests on the subject. I certainly didn't miss that paper's pre-print at the time.
I believe the earliest birds were this team, who had been playing with Bungarotoxins on Neurones for 30+ years (re: L'Homme Neuronal) :
A nicotinic hypothesis for Covid-19 with preventive and therapeutic implications
Received: 2020-04-16
https://archive.is/THeQ7
https://comptes-rendus.academie-sciences.fr/biologies/item/CRBIOL_2020__343_1_33_0/
and spotted the problem and the solution right away, a mere 2 weeks *AFTER* agro-business magazines were advising here *against* taking Ivermectin for COVID.
Quote:
"The neurotoxin motifs. Amino acid sequence alignment of the motifs found in toxins from snakes of the Ophiophagus (cobra) and Bungarus genera, in G from three RABV strains and in S from SARS-CoV-2."
Nicotine is anti-parasitic https://www.newscientist.com/article/2138655-birds-use-cigarette-butts-for-chemical-warfare-against-ticks/
It is, but I doubt that's enough for those with harned lungs, or to stop longer term repeated exposures. Most Americans have been infected by now.
There’s a chart somewhere from the beginning of 2020-ish showing flu-like deaths from 2017-18 being an ordinary out-of-the-ordinary spike in the chart of flu deaths. Ordinary because such a spike happens every so many flu seasons, and it was roughly on schedule. Out-of-the-ordinary because it was taller than the others. I can’t seem to find it now. And back then I didn’t know all this type of stuff needed to be screen grabbed.
Anyway, I’ve been thinking along the lines of this article for some time due to that flu chart, and because of my own experiences through the last five years. I got “pneumonia” in 2017, and so did many around me in the small town I lived in at the time (pacific northwest). The people I know that got that sickness or similar to it at that time didn’t get COVID at all over the last 2 years. Despite several exposures. Our own conversations have included speculation of cross-immunity with respect to the underlying cause of that 2017 sickness. Consider also, that in the US, the Pacific Northwest has shown more resilience to COVID, when looking at the data. Even though the data are corrupt, it is roughly apples to apples in this way. I wonder where else that mystery pneumonia blew up and how the COVID numbers look there now?
Back in 2017, I was convinced that we had a “cousin” of MERS, because the experience closely matched what I read about it, and we were exposed to vectors for MERS, even though it was considered no big deal by then. My current hypothesis is that they’ve been trying to “burn the house down” since at least 2003-4 with SARS-CoV, 2008-9 with H1N1, 2013-4 MERS and avian flu, 2017-8 no-name, 2019+ SARS-CoV-[x]. But something always put the fire out (because they’re not actually in control like they like to think they are). The conspirators in this hypothesis didn’t realize that a perception that the house was burning down was more effective and easier to pull off. Thus, COVID-19 was born.
Extending the conspiracy theory further, one might conclude that the jabs were a fire they could guarantee because it’s going straight into the blood - OR - that it was a money grab, seizing the opportunity presented by everyone running out of the house panicked, but will nevertheless burn the house down as an unintended intended consequence. Like an arsonist that keeps failing, then decides to dupe the homeowners into letting him inside to “fix” a problem that doesn’t exist. He either intends to set the house ablaze from within, or maybe he changed his intention to merely stealing everything valuable but then clumsily bumps a candle into a curtain and burns the house down anyway, having unintentionally succeeded in his original endeavor. Or maybe a little of both. I’m not sure yet, because Moderna folks seem to act like the first type, while Pfizer folks seem to act like the second. Every once in a while, I get the distinct feeling that animal doctor Bourla isn’t happy with his role in this. His guilt and humanity occasionally leak.
This theory would also explain why ~80% of the population seems to be immune. Case in point, the USS Roosevelt, where even in the tight quarters, only 20% of the crew contracted the virus. There have been many other instances showing that only about 20% of the population is actually susceptible, or capable of "catching COVID".
In 2019, the Navy had an uptick in illness. Something I noticed in the DMED.
That adds another dimension of authenticity to your theory.
I've considered myself "Ground Zero" for herd immunity. I've played with Corona viruses in many species due to my work for the last 30 years. I've gone to help friends who have been ill, or quarantined due to "SARS-CoV2", because I've had no fear. Yet, even in close quarters with many that are ill, and/or test positive, I have yet to have so much as a sniffle. If it was as bad as the media and Fraudci portrayed, I should have been ill and dead 2+ years ago. I guess all of my previous Corona virus exposures conferred cross protection. (Maybe it wasn't so novel after all?) But if they tell us "they missed the strain of the flu virus circulating this year, but you should run out and get vaccinated anyway, because you get cross protection", how can they not realize that even having antibodies to the common cold, (also a Corona virus) is cross protective?
I think they KNOW there is cross protection, but that doesn't feed the fear. Not only that, but over 70% of the surface proteins are the same as other Corona viruses. (Again, maybe it isn't so novel).
The spike with the FCS is the only novel part.
That's not suspicious or anything.
Heard about the quasispecies swarm from Dan Sorotkin at Harvard2TheBigHouse substack a while back. His theory was that the virus was originally a Live Attenuated Virus Vaccine that was released at the Chinese Military Games or possibly earlier and is mutating back to a more virulent/original form prior to the attenuation procedure. This would fit in nicely with your musings here, Matthew.
You used my favorite word, "lofty"!
Nice sleuthing (that is the right work for investigative work?)!
To add on: where are the vaping equipment manufactured? I'd guess that PRC gets you your money back minus commission. Are they put together in a sterile workc environment? Anyone thinks that about chinese manufacturing, I've got a bridge to sell you in Tamanrasset.
What I'm saying is, could it be so simple that the soon-to-be-the-Covid we know virus was initially spread by contaminated shipments of vaping gear?
After all, people needing oral stimulation suck those things. What if workers putting them together had colds? I don't think you get sick days with pay in chinese factories, meaning you work until you can't (ain't capitalism grand?).
So a lot of the people sucking the fashionable pacifiers might of simply licked themselves a little prior infection, and that way developing as you say better prtection but higher susceptibility (kind like how a person who's had the clap multiple times is more susceptible to infection, should the condom break).
Again, great detective work.
Why China? If the virus has been circulating longer, it was almost surely made by Baric & Co, if not people at Ft. Derrick whom he trained.
Release through a variety of vape delivery products seems pretty far fetched when you compared some the more ordinary, "left the jar open" method.
I'm just speculating since the majority of cheap products are made there, and China not being known for any kind of labour or environmental regulations.
(Re-reading my initial post I see why I shouldn't write before coffee - egads, grammar and spelling worthy of the US president.)
And as an aside concerning how a contaminant may be released:
I know two people working garbage collection/sorting in Sweden. One at the conveyor belt (yes, we use manual labour for that, lowest legal wage of course and no prior training needed - it is typically done by ex-cons, migrants and disabled/cognitive deficient meaning the company gets the wage subsidised) and well, at least once a week they find canisters or containers marked "Biohazard" coming from labs or hospitals. Anything from used needles to unlabeled vials of who knows what. Those canisters are not supposed to ever go in the regular garbage.
One works managerial level. He can tell the real juicy storys. Hand grenades, a couple every year at least. As in - someone tossed a real grenade out with their regular trash. Top of his sh*t-list was a container marked "Radioactive waste". In the regular garbage. A 75 kilo container of radioactive waste ditched in a garbage dumpster somewhere. No trail.
That's here in Sweden where they shut down the line upon such incidents (the entire plant for explosives and radioactive materials). Now imagine how China handles it.
That's why I started thinking maybe some chinese person simply sneezed at enough mouthpieces during two weeks.
Great theory! And I love a great theory that comes with a side of cute furry animals.
Science is so cool, it's unfortunate that people don't know how creative it is, to come up with problem solving theories about our world that can be discussed and proven true or false or unknown. 💫
At a US county level, smoking rates were more predictive of Covid deaths than vax rates. My intuition was that smoking was simply a marker of poorer general health.
https://inumero.substack.com/p/best-predictor-of-covid-deaths-in?r=tv61s&s=w&utm_campaign=post&utm_medium=web&utm_source=direct
What would the curve look like for an inhalation product?
Probably closer to a uniform distribution with clear signals tied to specific, but not broad manufacturers.
I've always wondered if the vaping illness wasn't just part of some experiment, not with the actual virus, but perhaps spike protein, or graphene dioxide, or different combinations.
Perhaps an artificial self replicating "vaccine?"
I considered that hypothesis, but the basic evidence stands against it. The hospitalization curve alone conforms to expectations of viral spread and it would be magnificently fortuitous for product distribution to achieve R that just happens to compress with seasonality.
Bet against any splitting of the arrow hypothesis.
Thanks for the reply, and I just wondered if it wasn't some "artificial" virus type agent because the other data ruled simple contaminants out?
Here is a great two part on the quasi species https://harvard2thebighouse.substack.com/p/understanding-covid-19-and-seasonal. Or just search pandoras golden silkworm
He would have done well to set his articles up with a clear story of what the quasispecies swarm means. I read his first article twice and in pieces before I knew what reading to do to build a background on the topic.
I wish I could go back and accelerate his broadcast by doing so myself, but I had my own priorities. And it's done here now.
You add an interesting twist to the theory. I know early on in France they had noticed smokers seemed to face lower covid incidence rates, so were set to conduct a study, nicotine focused I believe. Not sure if the study was conducted. (Anti-smoking groups which became aware of the proposed study immediately went into action to fight that narrative.) But that covid, before we knew of the outbreak, could be selectively targeting weakened lungs of smokers, so seeming to provide smokers with lower infection rates because they'd already naturally gained immunity from previous infection is an interesting thought. One issue though, if I remember correctly, EVALI (e-cigarette or vaping associated lung injury) was affecting predominantly the young, which goes against our early experience with known covid. There were about 2600 EVALI US cases. I don't remember, so someone correct me, were there cases in other countries? And this was for vapers; tobacco or THC. Did we also see unusual respiratory issues in analog cigarette smokers during the pre-covid period when EVALI occurred?
Not that I don't think covid seems to have been with us well before it was first announced. There's the European sewage samples showing early 2019 contamination. And the Italy stored lung tissue for the cancer study from early Semptember-ish 2019.
"Anti-smoking groups which became aware of the proposed study immediately went into action to fight that narrative."
Just like... let's generously call them "anti-vaccine-hesitancy groups"... becoming aware of the potential for successful early covid treatments belying the need for mass vaccination, and springing into action to fight the early-treatment narrative.
An unholy alliance between the FDA, anti-tobacco groups and Big Tobacco. 480,000 annual US cigarette related deaths and you can't get any of them to recommend the safer alternative, vaping.
Smoking and vaping are different. Smoking puts hot air and nicotine down into the oral cavity and lungs and maybe nasal one and heat tends to kill the virus. Also nicotine has been found to interfere with the virus attaching to the cells because it attaches to the same receptors and was shown in one study to help heal long Covid. I doubt vaping interferes with a SARS-CoV-2 viral infections the same way smoking does. I do not recommend smoking, which has other downsides.